SKAP1

Name	src kinase associated phosphoprotein 1
Structure
Novel Interactors	2 novel interactors: ELOC TBKBP1
Interactors	13 interactors: APP BLCAP DYNLL2 EEIG1 FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
GO Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion
GWAS	Body mass index ( 25673413 28892062 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Epithelial ovarian cancer ( 25581431 ) Food allergy ( 29030101 ) Generalized epilepsy ( 22949513 ) HDL cholesterol levels ( 32203549 ) Intelligence ( 28530673 ) Keratoconus ( 33649486 ) Lean body mass ( 28552196 ) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880 ) Ovarian cancer ( 20852632 ) Peanut allergy ( 29030101 ) Pulse pressure ( 30578418 ) White blood cell count ( 32888494 )
Entrez ID	8631
HPRD ID	05396
Ensembl ID	ENSG00000141293
Uniprot IDs	Q86WV1 V9HW03
PDB IDs	1U5D
GO Terms Enriched among Interactors ?	Ephrin Receptor Binding Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Membrane Raft T Cell Costimulation Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune System Process Signaling Receptor Binding Positive Regulation Of Cell Activation Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Signaling Receptor Activator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation Regulation Of Immune System Process Phospholipase Activator Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Scaffold Protein Binding Immune System Process Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Regulation Of T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Defense Response Protein Tyrosine Kinase Activity CD8 Receptor Binding Growth Factor Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway