THOC3

Name	THO complex subunit 3
Structure
Interactors	7 interactors: BRCA1 DDX39B DLG4 MLKL PFKFB4 PTEN TK1
GO Annotations	Cellular Component	Transcription Export Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	RNA Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing MRNA Transport
Pathways	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
GWAS	Chronotype ( 30696823 )
Entrez ID	84321
HPRD ID	09497
Ensembl ID	ENSG00000051596
Uniprot IDs	Q96J01
PDB IDs	7APK 7ZNK 7ZNL
GO Terms Enriched among Interactors ?	Dendritic Spine Morphogenesis Identical Protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Social Behavior Dendritic Spine Organization Postsynapse Organization P2Y1 Nucleotide Receptor Binding Negative Regulation Of Synaptic Vesicle Clustering Small Molecule Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein-containing Complex Assembly PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Thymidine Kinase Activity Cellular Component Assembly Beta-1 Adrenergic Receptor Binding Regulation Of Nervous System Process Regulation Of Grooming Behavior ATP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission DNA Synthesis Involved In Mitotic DNA Replication Execution Phase Of Necroptosis Protein-containing Complex Organization BRCA1-B Complex Cellular Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Phase Transition AMPA Glutamate Receptor Clustering Dendritic Spine Neuroligin Family Protein Binding Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Thymidine Biosynthetic Process Negative Regulation Of Centriole Replication Negative Regulation Of Cellular Component Organization Nuclear Ubiquitin Ligase Complex BRCA1-C Complex