TRMT1L

Name	tRNA methyltransferase 1L
Structure	No pdb structure
Interactors	8 interactors: APP MIR106A MIR141 MIR17 MIR34A MIR93 PRPF6 SUMO2
GO Annotations	Cellular Component	Nucleus Nucleolus
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding TRNA (guanine) Methyltransferase Activity Transferase Activity Metal Ion Binding TRNA (guanine(27)-N2)-dimethyltransferase Activity
	Biological Process	TRNA N2-guanine Methylation TRNA Processing Methylation
GWAS	Hand grip strength ( 29691431 )
Entrez ID	81627
HPRD ID	12722
Ensembl ID	ENSG00000121486
Uniprot IDs	B4DXX1 Q7Z2T5
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Post-transcriptional Gene Silencing Regulation Of Vascular Endothelial Growth Factor Production Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle RISC Complex Regulation Of Chemokine Production Negative Regulation Of Chemokine Production Response To Norepinephrine Cellular Response To Norepinephrine Stimulus MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Cytokine Production Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Connective Tissue Replacement Regulation Of Cytokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cholesterol Efflux Regulation Of Connective Tissue Replacement Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Translation Negative Regulation Of Glycoprotein Metabolic Process Cellular Response To Catecholamine Stimulus Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Amyloid-beta Clearance Response To Catecholamine Regulation Of Osteoblast Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Tissue Remodeling Negative Regulation Of Cholesterol Transport Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Interleukin-8 Production Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Catabolic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process