BRD3

Name	bromodomain containing 3
Structure
Novel Interactors	1 novel interactors: TSC1
Interactors	6 interactors: APP BRD7 MAP1LC3B MYC SPOP SPP1
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Histone H3K18cr Reader Activity Histone H3K9cr Reader Activity Histone H3K27cr Reader Activity Histone Reader Activity Molecular Condensate Scaffold Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endodermal Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Protein Localization To Chromatin
GWAS	Alanine aminotransferase levels ( 34315874 ) Alcohol consumption (drinks per week) ( 30643258 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 ) Brain-derived neurotrophic factor levels ( 33345186 ) Central corneal thickness ( 31798171 29760442 ) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Eosinophil count ( 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Estimated glomerular filtration rate ( 31152163 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol levels ( 32203549 ) Immature fraction of reticulocytes ( 32888494 ) Intraocular pressure ( 29617998 30591961 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Neutrophil count ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Platelet count ( 32888494 22139419 ) Platelet distribution width ( 27863252 ) Red cell distribution width ( 28957414 32888494 27863252 ) Sum basophil neutrophil counts ( 27863252 ) Sum eosinophil basophil counts ( 27863252 )
Entrez ID	8019
HPRD ID	03327
Ensembl ID	ENSG00000169925
Uniprot IDs	Q15059
PDB IDs	2E7N 2NXB 2OO1 2YW5 3S91 3S92 5A7C 5HFR 5HJC 6BGG 6BGH 6I41 6I5P 6I68 6I7A 6QJU 6U4A 6ULP 7JMY 7JQ8 7JYN 7JYZ 7L72 7L9L 7LAY 7LAZ 7LB4 7LBT 7R8R 7RJK 7RJL 7RJM 7RJN 7S3P 7TO7 7TO8 7TO9 7TOA 7UG5 8B5A 8CV5
GO Terms Enriched among Interactors ?	Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To Stress Striated Muscle Cell Differentiation Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Ubiquitin Protein Ligase Binding Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Memory T Cell Differentiation Regulation Of Cell Cycle Adult Locomotory Behavior Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Regulation Of Cellular Component Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Peptide Response To Cytokine Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization NK T Cell Proliferation Myc-Max Complex Muscle Cell Differentiation Regulation Of Acinar Cell Proliferation Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Response To Nutrient Levels TSC1-TSC2 Complex Response To Norepinephrine Integrin Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway