ALG8

Name	ALG8 alpha-1,3-glucosyltransferase
Structure	No pdb structure
Novel Interactors	4 novel interactors: IQGAP2 NARS2 RSF1 TMEM126B
Interactors	12 interactors: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
Pathways	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes CDG-1h
Diseases	Congenital disorders of glycosylation (CDG) type I
GWAS	Depression in smokers ( 30219690 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Tourette syndrome ( 30818990 )
Entrez ID	79053
HPRD ID	10480
Ensembl ID	ENSG00000159063
Uniprot IDs	A0A024R5K5 A0A7P0TA89 A0A7P0TAA8 A0A7P0Z449 A0A804G6E3 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YEE0 Q9BVK2
PDB IDs	Not available