TBX5

Name	T-box transcription factor 5
Structure
Interactors	7 interactors: BAIAP2 FBXO25 GATA4 KAT5 KDM6A NKX2-5 ZMYND10
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Cell Fate Specification Morphogenesis Of An Epithelium Sinoatrial Node Development Bundle Of His Development Atrioventricular Bundle Cell Differentiation Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Gap Junction Assembly Positive Regulation Of Cardiac Conduction
Pathways	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis
Diseases	Holt-Oram syndrome
GWAS	Airflow obstruction ( 22837378 ) Atrial fibrillation ( 30061737 33990960 29892015 28416822 28416818 ) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 ) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027 ) Blood pressure ( 21909110 ) Bone mineral density (total hip) ( 29883787 ) Brugada syndrome ( 35210625 ) Diastolic blood pressure ( 19430479 28135244 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diverticular disease ( 30177863 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) FEV1 ( 30804560 ) Hypertension ( 30487518 ) Laryngeal squamous cell carcinoma ( 25194280 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Mean arterial pressure ( 30487518 ) Obesity-related traits ( 23251661 ) P wave duration ( 28794112 ) Peak expiratory flow ( 30804560 ) Pelvic organ prolapse ( 32184442 ) Percent mammographic density ( 22532574 ) PR interval ( 32439900 20062060 30046033 25035420 23139255 21347284 ) Prostate cancer ( 25939597 23535732 ) QRS duration ( 30012220 27577874 21076409 ) Receptive language ability ( 32635940 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure ( 27618452 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355 ) Visceral fat ( 22589738 )
Entrez ID	6910
HPRD ID	03372
Ensembl ID	ENSG00000089225
Uniprot IDs	Q99593
PDB IDs	2X6U 2X6V 4S0H 5BQD
GO Terms Enriched among Interactors ?	Atrioventricular Node Development Atrial Septum Morphogenesis Aortic Valve Morphogenesis Cardiac Muscle Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Morphogenesis DNA-binding Transcription Activator Activity Cardiac Muscle Tissue Development Heart Development Septum Secundum Development Cardiac Septum Development Nkx-2.5 Complex Cardiac Septum Morphogenesis Purkinje Myocyte Differentiation Mesenchyme Development Regulation Of Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Differentiation Cardiocyte Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Muscle Cell Apoptotic Process Heart Valve Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Carbohydrate Stimulus Dendritic Spine Cytoplasm Neuron Projection Branch Point Histone H2AK5 Acetyltransferase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Stem Cell Differentiation Regulation Of Cardiac Muscle Contraction Intracellular Glucose Homeostasis Muscle Cell Differentiation Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Regulation Of Striated Muscle Contraction Atrial Septum Secundum Morphogenesis Positive Regulation Of Organelle Organization Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Epithelial Tube Morphogenesis Striated Muscle Tissue Development His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Proepicardium Development Positive Regulation Of Developmental Process Regulation Of System Process Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis