CCL3

Name	C-C motif chemokine ligand 3
Structure
Novel Interactors	1 novel interactors: SEC11A
Interactors	12 interactors: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SNCA SRGN TGFB1 UBQLN1 UBQLN2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding CCR Chemokine Receptor Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Cell-cell Signaling Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Eosinophil Degranulation Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Host-mediated Suppression Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways	Chemokine receptors bind chemokines Interleukin-10 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs	ROX-888
GWAS	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Body mass index ( 26426971 )
Entrez ID	6348
HPRD ID	01656
Ensembl ID	ENSG00000277632
Uniprot IDs	A0N0R1 P10147
PDB IDs	1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 4RA8 4ZKB 5COR 5D65 7F1Q 7F1T
GO Terms Enriched among Interactors ?	Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Inflammatory Response Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemotaxis Calcium-mediated Signaling Locomotion Cytokine-mediated Signaling Pathway Response To Stress Regulation Of Calcium Ion Transport Immune Response Chemokine (C-C Motif) Ligand 5 Binding Immune System Process Negative Regulation Of Biomineral Tissue Development Defense Response Cell Migration Response To Cytokine Response To Peptide Regulation Of Metal Ion Transport Cell Motility External Side Of Plasma Membrane Negative Regulation Of Ossification G Protein-coupled Receptor Activity Positive Regulation Of Inflammatory Response Regulation Of Monoatomic Ion Transport Cellular Response To Cytokine Stimulus G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Transport Regulation Of Transport Dendritic Cell Chemotaxis Tolerance Induction Positive Regulation Of ERAD Pathway Negative Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Regulation Of Sequestering Of Calcium Ion Leukocyte Chemotaxis Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Chemotaxis Response To Cholesterol Regulation Of ERAD Pathway Regulation Of Calcium Ion Transmembrane Transport