TNFRSF17

Name	TNF receptor superfamily member 17
Structure
Novel Interactors	1 novel interactors: ABCC1
Interactors	8 interactors: CMTM7 PEX16 TMBIM6 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3
GO Annotations	Cellular Component	Plasma Membrane Endomembrane System Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway
Pathways	TNFs bind their physiological receptors
Drugs	Belantamab mafodotin Teclistamab Idecabtagene vicleucel Ciltacabtagene autoleucel
GWAS	Blood protein levels ( 30072576 ) Phenylephrine infusion rate during anesthesia ( 31455332 ) QT interval ( 19305408 ) Testicular germ cell tumor ( 26503584 )
Entrez ID	608
HPRD ID	00144
Ensembl ID	ENSG00000048462
Uniprot IDs	Q02223
PDB IDs	1OQD 1XU2 2KN1 4ZFO 6J7W 8HXQ 8HXR 8QY9 8QYA 8QYB
GO Terms Enriched among Interactors ?	Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding Regulation Of Immunoglobulin Production Signaling Adaptor Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Cytokine-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of DNA-binding Transcription Factor Activity Regulation Of Production Of Molecular Mediator Of Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Cytokine Activity Positive Regulation Of Immune Response Positive Regulation Of B Cell Proliferation Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction TORC2 Complex Disassembly Regulation Of B Cell Proliferation Lymphocyte Homeostasis ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization ABC-type Vitamin B12 Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Sphingolipid Transporter Activity Cell Death Apoptotic Process Endoribonuclease Inhibitor Activity Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Leukocyte Homeostasis Positive Regulation Of B Cell Activation Positive Regulation Of Germinal Center Formation Transitional One Stage B Cell Differentiation B-1a B Cell Differentiation Positive Regulation Of Immune System Process Signal Transduction Immune System Process Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex