HRH4

Name	histamine receptor H4
Structure
Novel Interactors	2 novel interactors: ALMS1 SERPINB7
Interactors	4 interactors: CCL16 GNA15 GNAI1 GNAO1
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Regulation Of MAPK Cascade
Pathways	Histamine receptors G alpha (i) signalling events
Drugs	Amitriptyline Clozapine Loxapine Chlorpromazine Amoxapine Doxepin Aripiprazole Pheniramine REV131 Histamine Mianserin
GWAS	Adult body size ( 32376654 ) Chronotype ( 30696823 ) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009 ) Lung cancer ( 34062886 ) Response to taxane treatment (docetaxel) ( 23006423 )
Entrez ID	59340
HPRD ID	06004
Ensembl ID	ENSG00000134489
Uniprot IDs	B2KJ49 Q9H3N8
PDB IDs	7YFC 7YFD 8HN8 8HOC 8JXT 8JXV 8JXW 8JXX 8YN9 8YNA
GO Terms Enriched among Interactors ?	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion GTPase Activity GTP Binding G Protein-coupled Receptor Binding Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion G Protein Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mu-type Opioid Receptor Binding Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Protein Transport D2 Dopamine Receptor Binding Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Relaxation Of Smooth Muscle Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Protein Localization Positive Regulation Of Glomerular Mesangial Cell Proliferation Leukocyte Migration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Microtubule-based Process Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Basal Body Cellular Response To Forskolin Regulation Of Relaxation Of Muscle Response To Forskolin Positive Regulation Of Transforming Growth Factor Beta Production G Protein-coupled Acetylcholine Receptor Signaling Pathway