PRRG2

Name	proline rich and Gla domain 2
Structure
Novel Interactors	6 novel interactors: CCL4 CYTH2 NKG7 PPP2R1A RTN4RL1 SNX15
Interactors	8 interactors: CRK FAM221A FATE1 NEDD4 NEDD4L SGTA WWTR1 YAP1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Blood Coagulation
GWAS	Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Red blood cell count ( 27863252 32888494 ) Schizophrenia ( 25056061 29483656 30285260 )
Entrez ID	5639
HPRD ID	09189
Ensembl ID	ENSG00000126460
Uniprot IDs	O14669 Q8TAS3
PDB IDs	9BVP 9BVQ
GO Terms Enriched among Interactors ?	Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Dendrite Development Negative Regulation Of Sodium Ion Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Proline-rich Region Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Bicellular Tight Junction Hippo Signaling Positive Regulation Of Cell Growth Negative Regulation Of Potassium Ion Transport Heart Process Regulation Of Neuron Projection Development Neuromuscular Junction Development Plasma Membrane Bounded Cell Projection Organization Neuron Projection Development Plasma Membrane Positive Regulation Of Protein Catabolic Process Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Meiotic Spindle Elongation Enterocyte Differentiation Protein Monoubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Growth Macromolecule Catabolic Process Mesenchyme Development Regulation Of Growth Regulation Of Dendrite Morphogenesis Helper T Cell Diapedesis Regulation Of Lymphocyte Migration Protein Phosphorylated Amino Acid Binding Cell Projection Organization Response To Cholecystokinin Regulation Of Developmental Process Receptor Internalization Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation