PRKG2

Name	protein kinase cGMP-dependent 2
Structure
Interactors	8 interactors: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS RAB11B WDR77
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Positive Regulation Of Chondrocyte Differentiation Tetrahydrobiopterin Metabolic Process Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization Negative Regulation Of Chloride Transport
Pathways	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Ca2+ pathway cGMP effects cGMP effects RAS processing
Drugs	Fostamatinib
GWAS	Blood pressure (smoking interaction) ( 25189868 ) Body size at age 10 ( 32376654 ) Height ( 19343178 31562340 28552196 18391951 33713608 25282103 23563607 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) HIV-1 susceptibility ( 22174851 ) Pubertal anthropometrics ( 23449627 ) Refractive error ( 32231278 ) Schizophrenia ( 33169155 ) Sleep duration (short sleep) ( 30846698 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )
Entrez ID	5593
HPRD ID	09034
Ensembl ID	ENSG00000138669
Uniprot IDs	A0A140VJM3 B4DLF9 B7ZA25 Q13237
PDB IDs	5BV6 5C6C 5C8W 5JIX 5JIZ 6BQ8
GO Terms Enriched among Interactors ?	Cadherin Binding Monoatomic Ion Transport Postsynaptic Cytosol Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process 6-pyruvoyltetrahydropterin Synthase Activity Oocyte Axis Specification Actin Binding Cytoplasm Regulation Of Monoatomic Ion Transport Myosin Light Chain Kinase Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Phosphothreonine Residue Binding Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Cell Cortex Aorta Smooth Muscle Tissue Morphogenesis Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Metal Ion Transport Beta-2 Adrenergic Receptor Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of Potassium Ion Export Across Plasma Membrane Phosphatidylinositol Phospholipase C Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Tetrahydrobiopterin Biosynthetic Process Constitutive Secretory Pathway Amyloid-beta Clearance By Transcytosis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cul4B-RING E3 Ubiquitin Ligase Complex Monoatomic Ion Transmembrane Transporter Activity Protein Modification Process Tonic Smooth Muscle Contraction Hypotonic Response Cellular Hypotonic Response Calmodulin Binding Bleb Assembly Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transport Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway