DDIT4

Name	DNA damage inducible transcript 4
Structure
Interactors	8 interactors: GSK3B HSPA4 HSPB2 HUWE1 LRIF1 LRRK2 PDPK1 TXNIP
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding 14-3-3 Protein Binding
	Biological Process	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Signal Transduction Neuron Differentiation Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process
Pathways	TP53 Regulates Metabolic Genes
GWAS	Blond vs. brown/black hair color ( 30531825 ) Body mass index ( 31513605 ) Heschl's gyrus morphology ( 25130324 ) Refractive error ( 32231278 )
Entrez ID	54541
HPRD ID	09662
Ensembl ID	ENSG00000168209
Uniprot IDs	Q9NX09
PDB IDs	3LQ9 7MOP
GO Terms Enriched among Interactors ?	Positive Regulation Of Post-translational Protein Modification Wnt Signalosome Protein Autophosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Regulation Of Post-translational Protein Modification Protein Localization To Mitochondrion Regulation Of Apoptotic Process Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Membrane Permeability Protein Serine Kinase Activity Intracellular Signaling Cassette Protein Phosphorylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Negative Regulation Of Programmed Cell Death Establishment Of Protein Localization To Organelle 3-phosphoinositide-dependent Protein Kinase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Autophagy Positive Regulation Of Protein Modification Process Phosphorylation Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Superior Temporal Gyrus Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Unfolded Protein