BRWD1

Name	bromodomain and WD repeat domain containing 1
Structure
Novel Interactors	2 novel interactors: ADD2 EIF4E
Interactors	18 interactors: APP APPL1 CALM1 COPS5 CUL4B FNDC3B HDAC7 HIVEP2 NRF1 NUTF2 PPP5C SMARCA4 SMARCD1 STAT3 SYT4 TAF1 TRIM55 TRIM63
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Motile Cilium Cell Projection Ciliary Membrane
	Molecular Function	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape
Pathways	Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes
GWAS	Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 33547301 ) Apolipoprotein B levels ( 32203549 ) Cognitive function ( 25644384 ) Daytime nap ( 33568662 ) Daytime sleep phenotypes ( 27126917 ) General cognitive ability ( 29844566 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Menarche (age at onset) ( 25231870 ) Platelet distribution width ( 32888494 ) Smoking initiation ( 33082346 ) Temperament (bipolar disorder) ( 22365631 ) Total cholesterol levels ( 30275531 )
Entrez ID	54014
HPRD ID	11683
Ensembl ID	ENSG00000185658
Uniprot IDs	Q9NSI6
PDB IDs	3Q2E
GO Terms Enriched among Interactors ?	Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Signaling Astrocyte Projection Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Cycle Process Titin Binding Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway NBAF Complex RSC-type Complex NpBAF Complex Regulation Of Cell Cycle Phase Transition GBAF Complex Protein Modification By Small Protein Conjugation Response To Lead Ion Modulation Of Chemical Synaptic Transmission Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleosome Disassembly Negative Regulation Of Glycolytic Process Epigenetic Regulation Of Gene Expression Neuronal Dense Core Vesicle Protein-DNA Complex Disassembly Post-translational Protein Modification Regulation Of Cellular Response To Stress Protein Import Into Nucleus Negative Regulation Of ATP Metabolic Process Regulation Of Endocytosis Nucleoplasm Import Into Nucleus Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process