VPS36

Name	vacuolar protein sorting 36 homolog
Structure
Interactors	8 interactors: CHMP6 RILP SNCA SNF8 SPRY2 TSG101 UBC VPS25
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Cytoplasm Lysosome Endosome Late Endosome Cytosol Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding
	Biological Process	Protein Transport Macroautophagy Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission
Pathways	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
GWAS	Lewy body disease ( 25188341 )
Entrez ID	51028
HPRD ID	12620
Ensembl ID	ENSG00000136100
Uniprot IDs	Q86VN1
PDB IDs	2HTH 2ZME 3CUQ
GO Terms Enriched among Interactors ?	Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Endosome Organization Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Membrane Fission Vacuolar Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Receptor Activity Regulation Of ERBB Signaling Pathway Regulation Of Phosphorus Metabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein Metabolic Process Endosomal Transport Regulation Of Exosomal Secretion Endosome Membrane Membrane Organization Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Tyrosine Kinase Activity Vesicle Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Establishment Of Localization In Cell Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Late Endosome Membrane Regulation Of Phosphorylation Macroautophagy ESCRT II Complex Regulation Of Exocytosis Vesicle-mediated Transport Regulation Of Protein Kinase Activity Establishment Of Protein Localization To Vacuole Regulation Of Kinase Activity Regulation Of Protein Modification Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Exocytosis Autophagy Organelle Assembly Endosome Protein Localization To Vacuole Organelle Organization Negative Regulation Of Protein Phosphorylation