DHH

Name	desert hedgehog signaling molecule
Structure
Interactors	3 interactors: HHIP PTCH1 PTCH2
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Metal Ion Binding Cholesterol-protein Transferase Activity
	Biological Process	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Protein Autoprocessing Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Regulation Of Steroid Biosynthetic Process Self Proteolysis
Pathways	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np Transcriptional regulation of testis differentiation
Diseases	46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS	Bipolar disorder ( 31043756 ) Body mass index ( 25673413 ) Brain morphology (MOSTest) ( 32665545 ) Lumbar spine bone mineral density ( 22504420 )
Entrez ID	50846
HPRD ID	05664
Ensembl ID	ENSG00000139549
Uniprot IDs	O43323
PDB IDs	2WFQ 2WFR 2WG3 3N1G 3N1Q
GO Terms Enriched among Interactors ?	Hedgehog Family Protein Binding Negative Regulation Of Smoothened Signaling Pathway Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Regulation Of Smoothened Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Cell Fate Determination Ciliary Membrane Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Regulation Of Epidermis Development Cell Fate Specification Neural Plate Axis Specification Branching Morphogenesis Of An Epithelial Tube Epidermis Development Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epithelial Cell Differentiation Response To Chlorate Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regionalization Tube Morphogenesis Morphogenesis Of An Epithelium Cell Proliferation Involved In Metanephros Development Patched Binding Mammary Gland Duct Morphogenesis Neural Tube Patterning Dendritic Growth Cone Pattern Specification Process Neural Tube Formation Metanephric Collecting Duct Development Tissue Morphogenesis Cell Proliferation Involved In Kidney Development Dorsal/ventral Neural Tube Patterning Negative Regulation Of Multicellular Organism Growth Collecting Duct Development Commissural Neuron Axon Guidance Hair Cycle Somite Development Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Division Cellular Response To Cholesterol Mammary Gland Epithelial Cell Differentiation Pharyngeal System Development