SERPINB2

Name	serpin family B member 2
Structure
Novel Interactors	1 novel interactors: DCC
Interactors	8 interactors: APP CDC42 IRF3 PLAU PRPF8 PSMB1 RB1 UBE3A
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Cytoplasm Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Fibrinolysis Negative Regulation Of Apoptotic Process
Pathways	Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs	Urokinase Tenecteplase Lanoteplase
GWAS	Asthma ( 31619474 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Hen's egg allergy ( 29051540 ) Hip circumference adjusted for BMI ( 28552196 ) Systolic blood pressure ( 29208002 )
Entrez ID	5055
HPRD ID	01420
Ensembl ID	ENSG00000197632
Uniprot IDs	P05120
PDB IDs	1BY7 1JRR 2ARQ 2ARR
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Apoptotic Process Cell Projection Morphogenesis Growth Cone Lamellipodium Regulation Of Growth Neuron Projection Organization Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Regulation Of Signal Transduction Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Programmed Cell Death Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Neuron Projection Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Receptor Ligand Activity Endocytosis Cell Surface Receptor Signaling Pathway Regulation Of Inflammatory Response Lipoprotein Particle Cell Projection Organization Positive Regulation Of Cell Cycle Cell Death Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response