ASAH1

Name	N-acylsphingosine amidohydrolase 1
Structure
Interactors	6 interactors: CAMK1D HSPB2 SETDB1 SMPD1 SRPK1 TSC22D1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Early Endosome Endoplasmic Reticulum Membrane Lysosomal Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Corepressor Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Nuclear Receptor Binding N-acylsphingosine Amidohydrolase Activity Fatty Acid Amide Hydrolase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Ceramide Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor
Pathways	Neutrophil degranulation Glycosphingolipid catabolism Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Diseases	Farber lipogranulomatosis; Farber disease
GWAS	Atrial fibrillation ( 28416818 29892015 30061737 ) Night sleep phenotypes ( 27126917 ) Obesity ( 21552555 ) Type 2 diabetes ( 32499647 )
Entrez ID	427
HPRD ID	01969
Ensembl ID	ENSG00000104763
Uniprot IDs	A0A1B0GUE3 A8K0B6 Q13510 Q53H01
PDB IDs	5U7Z 6MHM
GO Terms Enriched among Interactors ?	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phosphatidylcholine Phospholipase C Activity Regulation Of Viral Life Cycle Positive Regulation Of Apoptotic Process Acid Sphingomyelin Phosphodiesterase Activity Positive Regulation Of Viral Process Regulation Of Viral Process Termination Of Signal Transduction Somatic Muscle Development Positive Regulation Of Endocytosis Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Sphingomyelin Catabolic Process Lamellar Body Sphingomyelin Phosphodiesterase Activity Histone H3K9 Monomethyltransferase Activity Endolysosome Histone H3K9me2 Methyltransferase Activity Positive Regulation Of Respiratory Burst Positive Regulation Of CREB Transcription Factor Activity Histone H3K9 Methyltransferase Activity