LCAT

Name	lecithin-cholesterol acyltransferase
Structure
Interactors	4 interactors: A2M APOA1 APOE EXOSC10
GO Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Exosome
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine-sterol O-acyltransferase Activity Phospholipase A2 Activity Sterol Ester Esterase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Apolipoprotein A-I Binding Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Aflatoxin Metabolic Process Phosphatidylcholine Metabolic Process Response To Copper Ion Response To Glucocorticoid Regulation Of High-density Lipoprotein Particle Assembly
Pathways	HDL remodeling
Diseases	Lecithin:cholesterol acyltransferase deficiency; Norum disease; Fish-eye disease
GWAS	HDL cholesterol ( 19060906 25961943 24507774 24097068 21347282 20864672 20686565 19060910 18193043 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 31217584 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 ) Total cholesterol levels ( 30275531 ) Total cholesterol levels in HDL ( 29084231 )
Entrez ID	3931
HPRD ID	06098
Ensembl ID	ENSG00000213398
Uniprot IDs	A0A140VK24 P04180
PDB IDs	4X96 4XWG 4XX1 5BV7 5TXF 6MVD
GO Terms Enriched among Interactors ?	Positive Regulation Of Phospholipid Efflux Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Lipoprotein Particle Binding Blood Microparticle High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Reverse Cholesterol Transport Endocytic Vesicle Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Negative Regulation Of Defense Response Cholesterol Efflux Positive Regulation Of Cholesterol Metabolic Process Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Efflux Signaling Receptor Binding Enzyme Binding Regulation Of Cholesterol Metabolic Process Cellular Response To Amyloid-beta Response To Amyloid-beta Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Positive Regulation Of Lipid Transport Phospholipid Transport Amyloid-beta Binding Extracellular Vesicle Regulation Of Rho Protein Signal Transduction Cholesterol Homeostasis