IFNA1

Name	interferon alpha 1
Structure
Novel Interactors	1 novel interactors: GLDC
Interactors	4 interactors: CR2 IFNAR1 IL2 IRF9
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Defense Response Humoral Immune Response Response To Exogenous DsRNA Symbiont Entry Into Host Cell Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Antiviral Innate Immune Response
Pathways	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
GWAS	No GWAS studies recorded
Entrez ID	3439
HPRD ID	00974
Ensembl ID	ENSG00000197919
Uniprot IDs	L0N195 P01562
PDB IDs	3UX9
GO Terms Enriched among Interactors ?	Type I Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Response To Virus Interferon-mediated Signaling Pathway Negative Regulation Of Adaptive Immune Response Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Cell Surface Receptor Signaling Pathway Via STAT Kappa-type Opioid Receptor Binding Lymphocyte Proliferation Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Mononuclear Cell Proliferation Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Catabolic Process Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Interferon Receptor Activity Regulation Of T Cell Homeostatic Proliferation Response To Tacrolimus ISGF3 Complex Positive Regulation Of Plasma Cell Differentiation Receptor Complex Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Interleukin-2 Receptor Binding Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Glycosphingolipid Binding Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Lymphocyte Differentiation Complement Receptor Activity Response To Other Organism Activated T Cell Proliferation Adaptive Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Defense Response To Virus Glycine Binding Cellular Response To Interferon-alpha Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Response To External Biotic Stimulus Negative Regulation Of Complement Activation Mononuclear Cell Differentiation Complement Receptor Mediated Signaling Pathway