HK2

Name	hexokinase 2
Structure
Interactors	10 interactors: ENO1 MAGEA12 PRKCE PROM1 PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Membrane Sarcoplasmic Reticulum
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor
	Biological Process	Response To Hypoxia Intracellular Glucose Homeostasis Response To Ischemia Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Hexose Metabolic Process Organophosphate Metabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of D-glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process Positive Regulation Of Type 2 Mitophagy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways	Glycolysis
GWAS	Femoral neck bone geometry ( 22087292 )
Entrez ID	3099
HPRD ID	03080
Ensembl ID	ENSG00000159399
Uniprot IDs	E9PB90 P52789
PDB IDs	2NZT 5HEX 5HFU 5HG1
GO Terms Enriched among Interactors ?	Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Perinuclear Region Of Cytoplasm Cellular Response To Oxygen Levels Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Hypoxia Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Store-operated Calcium Channel Activity Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Response To Oxygen Levels Endoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Prominosome Glomerular Parietal Epithelial Cell Differentiation Autophagosome Nuclear Proteasome Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Monoatomic Ion Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Negative Regulation Of Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Response To Ethanol Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process White Fat Cell Proliferation Positive Regulation Of Mucus Secretion Regulation Of Male Germ Cell Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytosolic Proteasome Complex Regulation Of Cellular Response To Stress Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Germ Cell Proliferation