CERS2

Name	ceramide synthase 2
Structure	No pdb structure
Novel Interactors	1 novel interactors: TNFSF4
Interactors	15 interactors: ASGR1 ASGR2 ATP6V0C CERS6 DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 UBC YIF1A
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Response To Immobilization Stress Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways	Sphingolipid de novo biosynthesis
GWAS	Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 26426971 ) Caffeine consumption from coffee or tea ( 33287642 ) Estimated glomerular filtration rate ( 31015462 31152163 ) Facial attractiveness (female raters) ( 30946739 ) Glycated hemoglobin levels ( 28898252 34059833 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 ) Reticulocyte fraction of red cells ( 27863252 ) Rhegmatogenous retinal detachment ( 23585552 )
Entrez ID	29956
HPRD ID	06080
Ensembl ID	ENSG00000143418
Uniprot IDs	Q96G23
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Cellular Response To Hypoxia Asialoglycoprotein Receptor Activity Regulation Of Cellular Response To Hypoxia Transmembrane Transport Ubiquitin Protein Ligase Binding Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Transmembrane Transport Membrane Fucose Binding Catecholamine Uptake Dopamine Uptake Protein Unfolding Azole Transmembrane Transport Plasma Membrane Pyrimidine-containing Compound Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Vitamin Transmembrane Transport Dopamine Transport Neurotransmitter Reuptake D-mannose Binding Monoatomic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Establishment Of Localization In Cell Monoamine Transport Neurotransmitter Uptake Organic Hydroxy Compound Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport COPII-coated ER To Golgi Transport Vesicle Pattern Recognition Receptor Activity Response To Cocaine Vitamin Transport CTP Binding DATP Binding Positive Regulation Of Glutathione Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Monoatomic Ion Transport Lateral Plasma Membrane G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Carboxylic Acid Transport Organic Acid Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding