GPI

Name	glucose-6-phosphate isomerase
Structure
Novel Interactors	1 novel interactors: DCC
Interactors	6 interactors: AMFR CSNK2A1 IGFBP3 LINC01554 PARP14 PCNA
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Ciliary Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Isomerase Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding Carbohydrate Derivative Binding
	Biological Process	In Utero Embryonic Development Mesoderm Formation Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Learning Or Memory Positive Regulation Of Endothelial Cell Migration Response To Estradiol Response To Progesterone Response To Testosterone Erythrocyte Homeostasis Response To Immobilization Stress Response To Muscle Stretch Glucose Homeostasis Negative Regulation Of Apoptotic Process Response To Cadmium Ion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process
Pathways	TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs	alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol
Diseases	Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Mean corpuscular volume ( 32888494 )
Entrez ID	2821
HPRD ID	01394
Ensembl ID	ENSG00000105220
Uniprot IDs	A0A2U3TZU2 B4DE36 P06744
PDB IDs	1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI 8BBH 8P2K 9FCW 9FHF 9FKC 9FKF
GO Terms Enriched among Interactors ?	Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Stress BAT3 Complex Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Regulation Of Growth Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Metabolic Process Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Protein Phosphorylation Insulin-like Growth Factor Binding Protein Complex Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Negative Regulation Of Phosphorylation PCNA Complex Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Aggrephagy Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Type II Interferon-mediated Signaling Pathway Derlin-1 Retrotranslocation Complex Insulin-like Growth Factor II Binding Regulation Of DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of SREBP Signaling Pathway Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Death Double-strand Break Repair Via Classical Nonhomologous End Joining Apoptotic Process Rhythmic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Programmed Cell Death Negative Regulation Of Collateral Sprouting