PTPN22

Name	protein tyrosine phosphatase non-receptor type 22
Structure
Novel Interactors	6 novel interactors: GSTP1 HMGCS2 ING4 NOTCH2 SARS1 WARS2
Interactors	13 interactors: CBL CD247 CD3E CLK1 CRK CSK EGFR GRB2 LCK PRKCD SRPK2 VAV1 ZAP70
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Immune System Process Lipid Metabolic Process Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphoanandamide Dephosphorylation Negative Regulation Of JUN Kinase Activity Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of P38MAPK Cascade
Pathways	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
Diseases	Type I diabetes mellitus
GWAS	Alopecia areata ( 25608926 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Arthritis (juvenile idiopathic) ( 33106285 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229 ) Autoimmune traits (pleiotropy) ( 30572963 ) Breast cancer ( 23535729 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 18587394 21102463 28067908 23128233 ) Giant cell arteritis ( 25817017 ) Granulocyte count ( 27863252 ) Graves' disease ( 22922229 ) Gut microbiota (bacterial taxa) ( 27694959 ) Hashimoto thyroiditis ( 22922229 ) Hodgkin's lymphoma ( 30194254 ) Hypothyroidism ( 22493691 27182965 ) Idiopathic inflammatory myopathy ( 26362759 ) IgM levels ( 28628107 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Late-onset myasthenia gravis ( 26562150 ) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083 ) Lymphocyte count ( 27863252 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Myasthenia gravis ( 23055271 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Obesity-related traits ( 23251661 ) Pediatric autoimmune diseases ( 26301688 ) Polymyositis ( 26362759 ) Rheumatoid arthritis ( 30423114 30572963 30891314 17554300 17804836 18794853 19503088 21156761 24449572 24390342 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Severe autoimmune type 2 diabetes ( 34737425 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 28714469 19838195 26502338 27399966 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Thyroid peroxidase antibody levels ( 24586183 ) Type 1 diabetes ( 21829393 17554260 17554300 17632545 25751624 19430480 30572963 18978792 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926 ) Vitiligo ( 27723757 20410501 ) White blood cell count ( 32888494 27863252 )
Entrez ID	26191
HPRD ID	06100
Ensembl ID	ENSG00000134242
Uniprot IDs	B4DZW8 F5H2S8 G3K0T4 Q9Y2R2
PDB IDs	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51 7AAM
GO Terms Enriched among Interactors ?	Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade T Cell Costimulation Cell-cell Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Immune System Process Leukocyte Activation Protein Tyrosine Kinase Binding T Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of T Cell Activation Fc Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion T Cell Activation Protein Kinase Activity Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Receptor Complex Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Gamma-delta T Cell Activation Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Positive Regulation Of Signal Transduction Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Protein Phosphatase Binding Regulation Of Cell Activation Gamma-delta T Cell Receptor Complex Ephrin Receptor Binding