PYGO1

Name	pygopus family PHD finger 1
Structure
Interactors	6 interactors: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Kidney Development Hematopoietic Progenitor Cell Differentiation Chromatin Organization Spermatid Development Spermatid Nucleus Differentiation Wnt Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway
Pathways	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
GWAS	Appendicular lean mass ( 33097823 ) Brain morphology (MOSTest) ( 32665545 )
Entrez ID	26108
HPRD ID	06064
Ensembl ID	ENSG00000171016
Uniprot IDs	Q9Y3Y4
PDB IDs	2VP7 2VPB 2VPD 2VPE 2VPG
GO Terms Enriched among Interactors ?	Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Beta-catenin-TCF Complex Histone Methyltransferase Activity Transcription Coactivator Activity Regulation Of Cell Communication Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Signaling Maintenance Of Cell Number Muscle Cell Differentiation Canonical Wnt Signaling Pathway Stem Cell Population Maintenance Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Regulation Of Timing Of Anagen Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Protein-containing Complex Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion