SWAP70

Name	switching B cell complex subunit SWAP70
Structure
Interactors	5 interactors: CELSR3 IGHG1 PARP1 RAPGEF4 ZBTB5
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Lamellipodium Cell Projection Postsynapse
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding ATP Binding Cadherin Binding
	Biological Process	Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Actin Polymerization Or Depolymerization Somatic Cell DNA Recombination Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Isotype Switching Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Mast Cell Chemotaxis
Pathways	RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
GWAS	Blood protein levels ( 30072576 ) Coronary artery disease ( 26343387 33020668 32469254 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Diastolic blood pressure ( 27841878 30487518 30224653 28739976 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 27863252 ) Hypertension ( 30487518 ) Mean arterial pressure ( 29403010 30487518 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 29403010 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Myocardial infarction ( 33532862 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Pulse pressure ( 27841878 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Rheumatoid arthritis ( 32723749 ) Systolic blood pressure ( 30578418 27841878 30487518 ) White blood cell count ( 32888494 )
Entrez ID	23075
HPRD ID	10378
Ensembl ID	ENSG00000133789
Uniprot IDs	B3KUB9 E7EMB1 Q9UH65
PDB IDs	2DN6
GO Terms Enriched among Interactors ?	NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity DNA ADP-ribosylation Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of ATP Biosynthetic Process NAD+-protein-serine ADP-ribosyltransferase Activity NAD DNA ADP-ribosyltransferase Activity Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Transcription Pausing By RNA Polymerase II Replication Fork Reversal Positive Regulation Of Necroptotic Process Mitochondrial DNA Repair Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Adipose Tissue Development Antibody-dependent Cellular Cytotoxicity Immunoglobulin Complex, Circulating Regulation Of Myofibroblast Differentiation Positive Regulation Of Mitochondrial Depolarization IgG Immunoglobulin Complex Immune Response Protein Auto-ADP-ribosylation Positive Regulation Of Programmed Necrotic Cell Death Transcription Regulator Activator Activity Adaptive Immune Response Hypersensitivity NAD+-protein-glutamate ADP-ribosyltransferase Activity Positive Regulation Of Membrane Depolarization Positive Regulation Of Adipose Tissue Development NAD+-protein-aspartate ADP-ribosyltransferase Activity