CASC3

Name	CASC3 exon junction complex subunit
Structure
Novel Interactors	1 novel interactors: STARD3
Interactors	17 interactors: AKT1 APC CASP8 CDK6 CDKN2A EIF4A3 ESR2 FGFR4 GRB2 KRTAP6-2 MIR128-1 NBN PHB1 PTPN1 PTPRJ STAU1 TSC1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Dendrite Nuclear Membrane Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Perinuclear Region Of Cytoplasm U2-type Catalytic Step 1 Spliceosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Regulation Of Translation Intracellular MRNA Localization RNA Splicing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GWAS	Asthma ( 31619474 ) Household income ( 31844048 )
Entrez ID	22794
HPRD ID	16225
Ensembl ID	ENSG00000108349
Uniprot IDs	O15234
PDB IDs	2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ 7W59 7W5A 7W5B 8I0W
GO Terms Enriched among Interactors ?	Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Lymphocyte Activation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Kinase Activity Leukocyte Activation Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Proteolysis Cell Activation Regulation Of Cell-substrate Adhesion Regulation Of Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Phosphorylation Protein Kinase Binding Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Regulation Of Immune System Process Regulation Of Biological Quality Negative Regulation Of Immune System Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Gene Expression Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Catabolic Process Positive Regulation Of Cell-matrix Adhesion Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Process