CRY2

Name	cryptochrome circadian regulator 2
Structure	No pdb structure
Novel Interactors	2 novel interactors: PTGES2 TNFRSF9
Interactors	53 interactors: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 FBXL21P FBXL3 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck Cry-Per Complex
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Phosphatase Inhibitor Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding FAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Protein Import Into Nucleus Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Response To Insulin Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
GWAS	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Axial length ( 24144296 ) Fasting blood glucose ( 20081858 22581228 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting glucose ( 34059833 ) Glycemic traits (pleiotropy) ( 31021400 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 30297969 ) Visceral fat ( 22589738 )
Entrez ID	1408
HPRD ID	07226
Ensembl ID	ENSG00000121671
Uniprot IDs	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Intermediate Filament Photoperiodism Regulation Of Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Keratin Filament Entrainment Of Circadian Clock Cytosol Circadian Regulation Of Gene Expression Circadian Rhythm Transcription Corepressor Binding Identical Protein Binding Response To Light Stimulus Response To Radiation Protein Phosphatase Type 2A Complex CLOCK-BMAL Transcription Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Binding Protein Phosphatase Regulator Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Thioesterase Binding Meiotic Sister Chromatid Cohesion E-box Binding Response To Redox State G1 To G0 Transition