PRDM4

Name	PR/SET domain 4
Structure
Novel Interactors	2 novel interactors: DAO UNG
Interactors	11 interactors: CFTR CTNNBL1 DYRK1A EIF4E EMX1 MSRB3 NCS1 RCAN1 RUNX1 SERTAD1 SMAD3
GO Annotations	Cellular Component	Nucleus Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways	p75NTR negatively regulates cell cycle via SC1
GWAS	Acne (severe) ( 24927181 ) Daytime nap ( 33568662 ) Sleep duration ( 30846698 )
Entrez ID	11108
HPRD ID	10425
Ensembl ID	ENSG00000110851
Uniprot IDs	B3KPI0 Q9UKN5
PDB IDs	2L9Z 3DB5
GO Terms Enriched among Interactors ?	Positive Regulation Of Extracellular Matrix Organization Transcription Coactivator Binding DNA-binding Transcription Factor Binding Transcription Corepressor Binding Enzyme Binding Response To Stress Positive Regulation Of Biomineral Tissue Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Histone H3T45 Kinase Activity Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Somatic Diversification Of Immunoglobulins