NFAT5

Name	nuclear factor of activated T cells 5
Structure
Novel Interactors	1 novel interactors: NUTF2
Interactors	5 interactors: ABL1 FOXP3 NFE2L2 TBC1D4 TRIM14
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Response To Stress DNA Damage Response Signal Transduction Positive Regulation Of Gene Expression Calcineurin-NFAT Signaling Cascade Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II R-loop Processing Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Cytokine Stimulus Cellular Hyperosmotic Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
GWAS	Adult body size ( 32376654 ) Blood osmolality (transformed sodium) ( 28360221 ) Blood urea nitrogen levels ( 31152163 29403010 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Chloride levels ( 29403010 ) Chronic kidney disease ( 29124443 ) Creatinine levels ( 29124443 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Hand grip strength ( 29691431 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828 ) Hyperuricemia ( 29124443 ) Intralaminar thalamic nuclei volume ( 34006833 ) Menarche (age at onset) ( 21102462 27182965 25231870 ) Metabolic syndrome ( 31589552 ) Pulse pressure ( 27841878 28135244 ) Self-reported risk-taking behaviour ( 30181555 ) Serum uric acid levels ( 30993211 29124443 ) Sjögren's syndrome ( 28076899 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Sodium levels ( 29403010 ) Triglyceride levels ( 32154731 ) Type 2 diabetes ( 30054458 30297969 ) Urate levels ( 31985003 23263486 )
Entrez ID	10725
HPRD ID	05272
Ensembl ID	ENSG00000102908
Uniprot IDs	O94916
PDB IDs	1IMH
GO Terms Enriched among Interactors ?	Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Fluid Shear Stress B Cell Homeostasis Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Fluid Shear Stress Negative Regulation Of Endothelial Cell Apoptotic Process T Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Apoptotic Process Regulation Of Stem Cell Differentiation Alpha-beta T Cell Differentiation Leukocyte Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Interleukin-2 Production Negative Regulation Of DNA Recombination Lymphocyte Homeostasis Protein Localization To Cytoplasmic Microtubule Plus-end B Cell Activation Involved In Immune Response Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Peripheral T Cell Tolerance Induction Transitional One Stage B Cell Differentiation Alpha-beta T Cell Activation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Podocyte Apoptotic Process DN4 Thymocyte Differentiation T Cell Receptor Signaling Pathway Response To Hydrogen Peroxide Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Lymphocyte Proliferation Cellular Response To Reactive Oxygen Species Inflammatory Response Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Establishment Of Endothelial Blood-brain Barrier Regulation Of Tolerance Induction Dependent Upon Immune Response CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment Mononuclear Cell Proliferation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Neuron Projection Development Positive Regulation Of RNA Biosynthetic Process T Cell Differentiation Response To Reactive Oxygen Species Microspike Assembly Nicotinate-nucleotide Adenylyltransferase Activity Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway B-1 B Cell Homeostasis Negative Regulation Of DNA Metabolic Process