POLD3

Name	DNA polymerase delta 3, accessory subunit
Structure
Interactors	7 interactors: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response Error-prone Translesion Synthesis DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair
Pathways	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
GWAS	Colorectal cancer ( 22634755 25990418 26151821 30529582 31826910 ) Colorectal cancer or advanced adenoma ( 30510241 ) Diastolic blood pressure ( 30224653 ) Hand grip strength ( 29313844 29691431 ) Microalbuminuria ( 26631737 ) Renal underexcretion gout ( 32238385 ) Response to metformin (IC50) ( 28173075 )
Entrez ID	10714
HPRD ID	11446
Ensembl ID	ENSG00000077514
Uniprot IDs	Q15054
PDB IDs	1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
GO Terms Enriched among Interactors ?	DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Translesion Synthesis Delta DNA Polymerase Complex Postreplication Repair DNA Replication DNA-directed DNA Polymerase Activity DNA Repair DNA-templated DNA Replication Error-free Translesion Synthesis Damaged DNA Binding DNA Metabolic Process Response To Light Stimulus DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Error-prone Translesion Synthesis DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Response To Radiation DNA Strand Elongation Response To UV Macromolecule Biosynthetic Process Cellular Response To Stress Response To Stress Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway PCNA Complex Replisome Nucleic Acid Metabolic Process Deoxycytidyl Transferase Activity DNA Binding Cellular Response To UV Nucleotidyltransferase Activity Chromatin Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Cellular Response To Light Stimulus Purine-specific Mismatch Base Pair DNA N-glycosylase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production