CD226

Name	CD226 molecule
Structure
Novel Interactors	4 novel interactors: CNDP2 DOK6 GALR1 TSHZ1
Interactors	4 interactors: FYN ITGB2 NECTIN2 PVR
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Signaling Receptor Activity Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Type II Interferon Production Positive Regulation Of Mast Cell Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Pathways	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Diseases	Type I diabetes mellitus
GWAS	Autoimmune thyroid disease ( 32581359 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic widespread musculoskeletal pain ( 33331911 ) Eosinophil count ( 32888494 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Inflammatory bowel disease ( 23128233 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean platelet volume ( 32888494 31194788 27863252 22139419 19820697 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 ) Neutrophil count ( 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 27863252 ) Plateletcrit ( 32888494 27863252 ) Primary sclerosing cholangitis ( 27992413 23603763 ) Reticulocyte fraction of red cells ( 32888494 ) Rheumatoid arthritis ( 24390342 30423114 ) Systemic lupus erythematosus ( 33272962 ) Type 1 diabetes ( 21829393 17554260 25751624 ) White blood cell count ( 32888494 )
Entrez ID	10666
HPRD ID	09252
Ensembl ID	ENSG00000150637
Uniprot IDs	J3QR77 Q15762
PDB IDs	6ISB 6O3O
GO Terms Enriched among Interactors ?	Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Cell Adhesion Molecule Binding Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Protein Targeting To Membrane Negative Regulation Of Immune Response Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Immune Effector Process Negative Regulation Of Defense Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Regulation Of Natural Killer Cell Mediated Immunity Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Regulation Of Immune Response Leukocyte Mediated Cytotoxicity Immune Effector Process Virus Receptor Activity Positive Regulation Of Immune System Process Focal Adhesion Response To Glycine Regulation Of Innate Immune Response Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Positive Regulation Of Defense Response Regulation Of T Cell Mediated Immunity Cell-cell Adhesion Negative Regulation Of Hydrogen Peroxide Biosynthetic Process ICAM-3 Receptor Activity