TUBB4A - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ABCA7	ATP binding cassette subfamily A member 7	ABC transporters in lipid homeostasis
Novel	APC2	APC regulator of Wnt signaling pathway 2			Colorectal cancer
Novel	BMPR2	bone morphogenetic protein receptor type 2	Signaling by BMP	Dibotermin alfa Fostamatinib
Novel	CEBPA	CCAAT enhancer binding protein alpha	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis		Acute myeloid leukemia (AML)
Novel	CLN8	CLN8 transmembrane ER and ERGIC protein			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
Novel	FNDC3B	fibronectin type III domain containing 3B
Novel	HMG20B	high mobility group 20B	HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Novel	KDM4B	lysine demethylase 4B	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Novel	LINC01554	long intergenic non-protein coding RNA 1554
Novel	NEAT1	nuclear paraspeckle assembly transcript 1
Novel	NR4A1	nuclear receptor subfamily 4 group A member 1	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Novel	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes
Novel	PLIN3	perilipin 3	Triglyceride catabolism Retrograde transport at the Trans-Golgi-Network Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy RHOBTB3 ATPase cycle	Idursulfase Galsulfase
Novel	RBM11	RNA binding motif protein 11
Novel	RSPH1	radial spoke head component 1
Novel	SBNO2	strawberry notch homolog 2
Novel	SELENOF	selenoprotein F
Novel	STAU1	staufen double-stranded RNA binding protein 1
Novel	STK11	serine/threonine kinase 11	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes		Peutz-Jeghers syndrome Pancreatic cancer
Novel	SUMO2	small ubiquitin like modifier 2	Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Regulation of endogenous retroelements by KRAB-ZFP proteins

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