TUBB4A and UQCR11

		TUBB4A	UQCR11
Description		tubulin beta 4A class IVa	ubiquinol-cytochrome c reductase, complex III subunit XI
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Axoneme Microtubule Cytoskeleton Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Intercellular Bridge Extracellular Exosome Mitotic Spindle	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding GTP Binding Metal Ion Binding	Electron Transfer Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Microtubule Polymerization	Generation Of Precursor Metabolites And Energy Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Cellular Respiration
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Respiratory electron transport Complex III assembly Complex III assembly
Drugs		Epothilone D Patupilone CYT997 ZEN-012 Artenimol	6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS		Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)
Interacting Genes		22 interacting genes: ABCA7 APC2 BMPR2 CEBPA CLN8 FNDC3B HMG20B KDM4B LINC01554 NEAT1 NR4A1 OGT PLIN3 RBM11 RSPH1 SBNO2 SELENOF STAU1 STK11 SUMO2 UQCR11 YWHAG	2 interacting genes: TUBB4A WNT2
Entrez ID		10382	10975
HPRD ID		04045	15628
Ensembl ID		ENSG00000104833	ENSG00000127540
Uniprot IDs		M0QZL7 M0R1I1 M0R278 P04350	O14957
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Non-canonical Inflammasome Complex Assembly LncRNA-mediated Post-transcriptional Gene Silencing Cellular Developmental Process	Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Atrial Cardiac Muscle Tissue Morphogenesis Cell Proliferation In Midbrain Iris Morphogenesis Lung Induction Regulation Of Branching Involved In Lung Morphogenesis Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Internode Region Of Axon Wnt Signalosome Midbrain Dopaminergic Neuron Differentiation Mammary Gland Epithelium Development Negative Regulation Of Microtubule Polymerization Cardiac Muscle Cell Proliferation Mesenchymal Cell Proliferation Placenta Blood Vessel Development Regulation Of Animal Organ Formation Positive Regulation Of Mesenchymal Cell Proliferation Labyrinthine Layer Blood Vessel Development Organ Induction Developmental Induction Frizzled Binding Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Muscle Cell Proliferation Dopaminergic Neuron Differentiation Regulation Of Mesenchymal Cell Proliferation Myelin Sheath Positive Regulation Of Heart Growth Lens Development In Camera-type Eye Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Microtubule Polymerization Or Depolymerization Muscle Cell Proliferation Positive Regulation Of Organ Growth Regulation Of Morphogenesis Of A Branching Structure Positive Regulation Of Fibroblast Proliferation Regulation Of Heart Growth Regulation Of Morphogenesis Of An Epithelium Cellular Response To Retinoic Acid Cardiac Muscle Tissue Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Microtubule Polymerization Response To Transforming Growth Factor Beta Muscle Tissue Morphogenesis Regulation Of Animal Organ Morphogenesis Epithelial To Mesenchymal Transition Regulation Of Embryonic Development Regulation Of Organ Growth Regulation Of Fibroblast Proliferation Neural Precursor Cell Proliferation Intercellular Bridge
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