TUBB4A and SBNO2

		TUBB4A	SBNO2
Description		tubulin beta 4A class IVa	strawberry notch homolog 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Axoneme Microtubule Cytoskeleton Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Intercellular Bridge Extracellular Exosome Mitotic Spindle	Nucleus
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding GTP Binding Metal Ion Binding	Chromatin DNA Binding Histone Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Microtubule Polymerization	Ossification Macrophage Activation Involved In Immune Response Regulation Of DNA-templated Transcription Cell Differentiation Bone Mineralization Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Bone Trabecula Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-11 Cellular Response To Interleukin-6 Multinuclear Osteoclast Differentiation Osteoclast Fusion Cellular Response To Leukemia Inhibitory Factor
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Epothilone D Patupilone CYT997 ZEN-012 Artenimol
Diseases
GWAS		Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)	Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Basal cell carcinoma ( 33549134) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Distal/Left-sided colorectal cancer ( 33632709) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010)
Interacting Genes		22 interacting genes: ABCA7 APC2 BMPR2 CEBPA CLN8 FNDC3B HMG20B KDM4B LINC01554 NEAT1 NR4A1 OGT PLIN3 RBM11 RSPH1 SBNO2 SELENOF STAU1 STK11 SUMO2 UQCR11 YWHAG	1 interacting genes: TUBB4A
Entrez ID		10382	22904
HPRD ID		04045	17203
Ensembl ID		ENSG00000104833	ENSG00000064932
Uniprot IDs		M0QZL7 M0R1I1 M0R278 P04350	Q9Y2G9
PDB IDs
Enriched GO Terms of Interacting Partners?		Non-canonical Inflammasome Complex Assembly LncRNA-mediated Post-transcriptional Gene Silencing Cellular Developmental Process	Internode Region Of Axon Negative Regulation Of Microtubule Polymerization Myelin Sheath Structural Constituent Of Cytoskeleton Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Supramolecular Fiber Organization Mitotic Spindle Mitotic Cell Cycle Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Or Depolymerization Axoneme Regulation Of Microtubule Polymerization Intercellular Bridge Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Microtubule Cytoskeleton GTPase Activity Microtubule Neuronal Cell Body GTP Binding Regulation Of Supramolecular Fiber Organization
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