TUBB4A and ABCA7

		TUBB4A	ABCA7
Description		tubulin beta 4A class IVa	ATP binding cassette subfamily A member 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Axoneme Microtubule Cytoskeleton Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Intercellular Bridge Extracellular Exosome Mitotic Spindle	Golgi Membrane Phagocytic Cup Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Membrane Cell Junction Early Endosome Membrane Ruffle Membrane Cell Projection Intracellular Membrane-bounded Organelle Glial Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding GTP Binding Metal Ion Binding	Nucleotide Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Microtubule Polymerization	Lipid Transport Phagocytosis Memory Visual Learning Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process Cholesterol Efflux Phospholipid Efflux Amyloid-beta Formation High-density Lipoprotein Particle Assembly Protein Localization To Nucleus Apolipoprotein A-I-mediated Signaling Pathway Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of MAPK Cascade Plasma Membrane Raft Organization Phospholipid Translocation Negative Regulation Of Endocytosis Positive Regulation Of Phagocytosis Transmembrane Transport Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Engulfment Of Apoptotic Cell Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipid Efflux Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Cell Surface
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	ABC transporters in lipid homeostasis
Drugs		Epothilone D Patupilone CYT997 ZEN-012 Artenimol
Diseases
GWAS		Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)	Alzheimer's disease ( 21460840 33074286 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 23571587 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Eosinophil percentage of white cells ( 27863252) Family history of Alzheimer's disease ( 30617256) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Serum metabolite levels ( 33031748) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		22 interacting genes: ABCA7 APC2 BMPR2 CEBPA CLN8 FNDC3B HMG20B KDM4B LINC01554 NEAT1 NR4A1 OGT PLIN3 RBM11 RSPH1 SBNO2 SELENOF STAU1 STK11 SUMO2 UQCR11 YWHAG	3 interacting genes: ADRB2 C5AR2 TUBB4A
Entrez ID		10382	10347
HPRD ID		04045	09255
Ensembl ID		ENSG00000104833	ENSG00000064687
Uniprot IDs		M0QZL7 M0R1I1 M0R278 P04350	B3KUJ3 Q8IZY2
PDB IDs			8EDW 8EE6 8EEB 8EOP 8Y1O 8Y1P
Enriched GO Terms of Interacting Partners?		Non-canonical Inflammasome Complex Assembly LncRNA-mediated Post-transcriptional Gene Silencing Cellular Developmental Process	Mitotic Spindle Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Intercellular Bridge Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy Microtubule Cytoskeleton AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Internode Region Of Axon Complement Component C5a Receptor Activity Complement Component C5a Signaling Pathway Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Neutrophil Migration Positive Regulation Of Autophagosome Maturation Heat Generation G Protein-coupled Receptor Activity Complement Receptor Activity Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Microtubule Polymerization Complement Receptor Mediated Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Cilium Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Leukocyte Chemotaxis Adaptive Thermogenesis Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Myelin Sheath Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Neutrophil Chemotaxis G Protein-coupled Receptor Signaling Pathway Temperature Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Regulation Of CAMP/PKA Signal Transduction Potassium Channel Regulator Activity
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