TUBB4A and STAU1

Number of citations of the paper that reports this interaction (PubMedID 15121898)
58

Data Source:
HPRD (in vitro)

		TUBB4A	STAU1
Description		tubulin beta 4A class IVa	staufen double-stranded RNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Axoneme Microtubule Cytoskeleton Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Intercellular Bridge Extracellular Exosome Mitotic Spindle	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Microtubule Associated Complex Plasma Membrane Cytoplasmic Stress Granule Membrane Dendrite Dendrite Cytoplasm Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Cell Body Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding GTP Binding Metal Ion Binding	RNA Binding Double-stranded RNA Binding MRNA Binding Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Microtubule Polymerization	LncRNA-mediated Post-transcriptional Gene Silencing Germ Cell Development Intracellular MRNA Localization Cellular Response To Oxidative Stress Protein Localization To Synapse Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Modulation Of Chemical Synaptic Transmission Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Modification Of Postsynaptic Structure Positive Regulation Of Long-term Synaptic Potentiation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Epothilone D Patupilone CYT997 ZEN-012 Artenimol
Diseases
GWAS		Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)	Anger ( 24489884) Appendicular lean mass ( 33097823) Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 32581322) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196 25282103) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		22 interacting genes: ABCA7 APC2 BMPR2 CEBPA CLN8 FNDC3B HMG20B KDM4B LINC01554 NEAT1 NR4A1 OGT PLIN3 RBM11 RSPH1 SBNO2 SELENOF STAU1 STK11 SUMO2 UQCR11 YWHAG	49 interacting genes: ADARB1 APP CASC3 CDC42 CEBPA CFTR CSNK2B DHX9 DYNC1I1 FMR1 FOXP1 GLRX3 HNRNPU INA IQGAP1 KIF2B LINC00624 LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NEIL3 NKRF NXT1 OGT PABPC1 PABPN1 PPP1CA RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 STRBP TAX1BP3 TINCR TUBB TUBB4A UBE2D3 UPF1 USP7 ZMAT3
Entrez ID		10382	6780
HPRD ID		04045	03422
Ensembl ID		ENSG00000104833	ENSG00000124214
Uniprot IDs		M0QZL7 M0R1I1 M0R278 P04350	B3KRE0 O95793 Q59F99 Q6PJX3
PDB IDs			4DKK 6HTU 6SDW 6SDY
Enriched GO Terms of Interacting Partners?		Non-canonical Inflammasome Complex Assembly LncRNA-mediated Post-transcriptional Gene Silencing Cellular Developmental Process	Cytoplasmic Ribonucleoprotein Granule Ribonucleoprotein Complex RNA Binding Cytosol Cytoplasm Nucleus Regulation Of Translation Regulation Of MRNA Metabolic Process MRNA Export From Nucleus Dendrite MRNA Transport Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing RNA Export From Nucleus RNA Transport Postsynapse Negative Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Process Cytoskeleton-dependent Intracellular Transport Cytoplasmic Translation Nuclear Export Negative Regulation Of Metabolic Process Nucleobase-containing Compound Transport Negative Regulation Of Macromolecule Metabolic Process Regulation Of Viral Process MRNA Processing Cell Body Regulation Of Cytoplasmic Translation CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleic Acid Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Protein-containing Complex Binding MRNA Binding Cytosolic Ribosome Positive Regulation Of Supramolecular Fiber Organization Transport Along Microtubule Regulation Of Supramolecular Fiber Organization Nuclear-transcribed MRNA Catabolic Process Cellular Localization Regulation Of RNA Splicing Regulation Of Viral Life Cycle Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation
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