UBB and SH3KBP1 |
ubiquitin B |
SH3-domain kinase binding protein 1 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Signaling by the B Cell Receptor (BCR)
- Signaling by EGFR
- EGFR downregulation
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Adaptive Immune System
|
|
|
|
|
UBB and FSHR |
ubiquitin B |
follicle stimulating hormone receptor |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- G alpha (s) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Hormone ligand-binding receptors
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
|
- Menotropins
- Follitropin beta
- Urofollitropin
- Choriogonadotropin alfa
- Suramin
|
|
|
UBB and LIG4 |
ubiquitin B |
ligase IV, DNA, ATP-dependent |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- HIV Life Cycle
- Nonhomologous End-joining (NHEJ)
- HIV Infection
- Integration of provirus
- Double-Strand Break Repair
- 2-LTR circle formation
- Early Phase of HIV Life Cycle
|
|
|
|
|
UBB and PIN1 |
ubiquitin B |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Negative regulators of RIG-I/MDA5 signaling
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
- Innate Immune System
|
|
|
|
|
UBB and HGS |
ubiquitin B |
hepatocyte growth factor-regulated tyrosine kinase substrate |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Signaling by EGFR
- EGFR downregulation
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
|
|
|
|
|
UBB and EPS15 |
ubiquitin B |
epidermal growth factor receptor pathway substrate 15 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Signaling by EGFR
- EGFR downregulation
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
|
|
|
|
|
UBB and MYBL2 |
ubiquitin B |
v-myb avian myeloblastosis viral oncogene homolog-like 2 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- G2/M Transition
- G0 and Early G1
- Mitotic G2-G2/M phases
- Mitotic G1-G1/S phases
- Polo-like kinase mediated events
- Cell Cycle, Mitotic
|
|
|
|
|
UBB and RAD23B |
ubiquitin B |
RAD23 homolog B (S. cerevisiae) |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Nucleotide Excision Repair
- Global Genomic NER (GG-NER)
- Formation of incision complex in GG-NER
- DNA Damage Recognition in GG-NER
- Dual incision reaction in GG-NER
|
|
|
|
|
UBB and MAPT |
ubiquitin B |
microtubule-associated protein tau |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Apoptotic cleavage of cellular proteins
- Programmed Cell Death
- Apoptotic execution phase
- Caspase-mediated cleavage of cytoskeletal proteins
|
|
|
|
|
UBB and NTRK2 |
ubiquitin B |
neurotrophic tyrosine kinase, receptor, type 2 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Signalling by NGF
- Activation of TRKA receptors
- NGF-independant TRKA activation
- NGF signalling via TRKA from the plasma membrane
|
|
|
|
|
UBB and CDC34 |
ubiquitin B |
cell division cycle 34 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
|
|
|
|
|
UBB and CDX2 |
ubiquitin B |
caudal type homeobox 2 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Peptide hormone metabolism
- Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
- Incretin synthesis, secretion, and inactivation
|
|
|
|
|
UBB and TRIM37 |
ubiquitin B |
tripartite motif containing 37 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
|
|
|
|
|
UBB and PARK2 |
ubiquitin B |
parkin RBR E3 ubiquitin protein ligase |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
|
|
|
|
|
UBB and UBE3A |
ubiquitin B |
ubiquitin protein ligase E3A |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
|
|
|
|
|
UBB and TRIM5 |
ubiquitin B |
tripartite motif containing 5 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Interferon gamma signaling
- Interferon Signaling
- Cytokine Signaling in Immune system
|
|
|
|
|
UBB and FANCD2 |
ubiquitin B |
Fanconi anemia, complementation group D2 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Fanconi Anemia pathway
- Regulation of the Fanconi anemia pathway
|
|
|
|
|
UBB and WWOX |
ubiquitin B |
WW domain containing oxidoreductase |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Nuclear signaling by ERBB4
- Signaling by ERBB4
|
|
|
|
|
UBB and USP1 |
ubiquitin B |
ubiquitin specific peptidase 1 |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- Fanconi Anemia pathway
- Regulation of the Fanconi anemia pathway
|
|
|
|
|
UBB and NR3C1 |
ubiquitin B |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
- Loss of Function of TGFBR2 in Cancer
- NF-kB is activated and signals survival
- Signaling by FGFR in disease
- Hedgehog 'off' state
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Signaling by NOTCH1
- Signaling by NOTCH2
- Toll Like Receptor 5 (TLR5) Cascade
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Stabilization of p53
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Downregulation of ERBB2:ERBB3 signaling
- TGFBR2 MSI Frameshift Mutants in Cancer
- Signaling by NOTCH
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Spry regulation of FGF signaling
- Signaling by NOTCH
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Regulation of innate immune responses to cytosolic DNA
- Autodegradation of the E3 ubiquitin ligase COP1
- Toll Like Receptor 3 (TLR3) Cascade
- Metabolism of carbohydrates
- CDK-mediated phosphorylation and removal of Cdc6
- Cellular response to hypoxia
- Hedgehog ligand biogenesis
- p75NTR recruits signalling complexes
- Fanconi Anemia pathway
- Separation of Sister Chromatids
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Synthesis And Processing Of GAG, GAGPOL Polyproteins
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- p53-Dependent G1 DNA Damage Response
- regulation of FZD by ubiquitination
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1
- p53-Independent DNA Damage Response
- MyD88:Mal cascade initiated on plasma membrane
- Stimuli-sensing channels
- Membrane binding and targetting of GAG proteins
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Downregulation of ERBB4 signaling
- Vpu mediated degradation of CD4
- Cell death signalling via NRAGE, NRIF and NADE
- ISG15 antiviral mechanism
- Interferon Signaling
- M/G1 Transition
- p75 NTR receptor-mediated signalling
- Signaling by FGFR
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by NOTCH1 in Cancer
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Downregulation of TGF-beta receptor signaling
- truncated APC mutants destabilize the destruction complex
- Cyclin E associated events during G1/S transition
- TGF-beta receptor signaling activates SMADs
- Regulation of PLK1 Activity at G2/M Transition
- FCERI mediated NF-kB activation
- Regulation of the Fanconi anemia pathway
- Generic Transcription Pathway
- G1/S Transition
- Toll Like Receptor 9 (TLR9) Cascade
- FBXW7 Mutants and NOTCH1 in Cancer
- IRAK1 recruits IKK complex
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- EGFR downregulation
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- IRAK2 mediated activation of TAK1 complex
- Processing-defective Hh variants abrogate ligand secretion
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Fc epsilon receptor (FCERI) signaling
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Interleukin-3, 5 and GM-CSF signaling
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- HIV Life Cycle
- Budding and maturation of HIV virion
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- IKK complex recruitment mediated by RIP1
- MAP kinase activation in TLR cascade
- Regulation of DNA replication
- Cytokine Signaling in Immune system
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by TGF-beta Receptor Complex in Cancer
- Oxidative Stress Induced Senescence
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Negative regulators of RIG-I/MDA5 signaling
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- SMAD2/3 MH2 Domain Mutants in Cancer
- T41 mutants of beta-catenin aren't phosphorylated
- Cellular Senescence
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by EGFRvIII in Cancer
- Assembly Of The HIV Virion
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- NOD1/2 Signaling Pathway
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Mitotic G1-G1/S phases
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- DNA Replication Pre-Initiation
- Senescence-Associated Secretory Phenotype (SASP)
- APC/C:Cdc20 mediated degradation of mitotic proteins
- TGFBR1 KD Mutants in Cancer
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Late Phase of HIV Life Cycle
- APC/C:Cdc20 mediated degradation of Cyclin B
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- TCR signaling
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- Interleukin-1 signaling
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Mitotic G2-G2/M phases
- Adaptive Immune System
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Ubiquitin-dependent degradation of Cyclin D
- G2/M Transition
- TGFBR1 LBD Mutants in Cancer
- Oncogene Induced Senescence
- Autodegradation of Cdh1 by Cdh1:APC/C
- Ion channel transport
- p75NTR signals via NF-kB
- Regulation of signaling by CBL
- XAV939 inhibits tankyrase, stabilizing AXIN
- Disease
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Signal Transduction
- Innate Immune System
- Synthesis of DNA
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- G1 Phase
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Ubiquitin-dependent degradation of Cyclin D1
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Regulation of mitotic cell cycle
- Signaling by Hedgehog
- Association of licensing factors with the pre-replicative complex
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- TCF7L2 mutants don't bind CTBP
- p53-Dependent G1/S DNA damage checkpoint
- Signaling by Wnt
- AUF1 (hnRNP D0) destabilizes mRNA
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- APC/C:Cdc20 mediated degradation of Securin
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRAK1 recruits IKK complex
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- Signaling by NOTCH1 in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- IRAK2 mediated activation of TAK1 complex
- Loss of Function of SMAD4 in Cancer
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- Glycogen synthesis
- NRIF signals cell death from the nucleus
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- SCF(Skp2)-mediated degradation of p27/p21
- Cyclin A:Cdk2-associated events at S phase entry
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Mitotic Metaphase and Anaphase
- Downstream TCR signaling
- Antigen processing: Ubiquitination & Proteasome degradation
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Orc1 removal from chromatin
- Mitotic Anaphase
- deactivation of the beta-catenin transactivating complex
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Signalling by NGF
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Cytosolic sensors of pathogen-associated DNA
- beta-catenin independent WNT signaling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Orc1 removal from chromatin
- Signaling by TGF-beta Receptor Complex
- CDT1 association with the CDC6:ORC:origin complex
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- SMAD4 MH2 Domain Mutants in Cancer
|
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
|
- Flunisolide
- Diflorasone
- Alclometasone
- Medrysone
- Amcinonide
- Fluorometholone
- Megestrol
- Beclometasone dipropionate
- Betamethasone
- Desoximetasone
- Fluticasone Propionate
- Fluocinolone Acetonide
- Halobetasol Propionate
- Triamcinolone
- Prednisone
- Flumethasone Pivalate
- Fludrocortisone
- Hydrocortisone
- Mometasone
- Hydrocortamate
- Mifepristone
- Clocortolone
- Flurandrenolide
- Prednisolone
- Loteprednol
- Rimexolone
- Methylprednisolone
- Clobetasol
- Fluocinonide
- Prednicarbate
- Fluoxymesterone
- Budesonide
- Dexamethasone
- Desonide
- Cortisone acetate
- Paramethasone
- Ciclesonide
- Hexane-1,6-Diol
- Difluprednate
- Fluticasone furoate
|
|
|