JAK1 and STAM2 |
Janus kinase 1 |
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 |
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Interleukin-7 signaling
- SOS-mediated signalling
- SHC-mediated signalling
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- GPCR downstream signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Downstream signal transduction
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- ISG15 antiviral mechanism
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- Signaling by PDGF
- DAP12 interactions
- Regulation of IFNA signaling
- G-protein beta:gamma signalling
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Signaling by ERBB2
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- G beta:gamma signalling through PI3Kgamma
- Downstream signaling of activated FGFR
- Interferon alpha/beta signaling
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- ERK2 activation
- Regulation of IFNG signaling
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- Signaling by EGFR
- EGFR downregulation
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
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JAK1 and STAM |
Janus kinase 1 |
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Interferon gamma signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Interleukin-7 signaling
- SOS-mediated signalling
- SHC-mediated signalling
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- ERK1 activation
- GPCR downstream signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Downstream signal transduction
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Axon guidance
- IRS-mediated signalling
- Interleukin-6 signaling
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Signaling by Insulin receptor
- Insulin receptor signalling cascade
- ISG15 antiviral mechanism
- Interferon Signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Signaling by GPCR
- FCERI mediated MAPK activation
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Toll Like Receptor 9 (TLR9) Cascade
- Signaling by PDGF
- DAP12 interactions
- Regulation of IFNA signaling
- G-protein beta:gamma signalling
- GRB2 events in EGFR signaling
- SHC-related events triggered by IGF1R
- Signaling by ERBB4
- Antiviral mechanism by IFN-stimulated genes
- Signaling by ERBB2
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-3, 5 and GM-CSF signaling
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- G beta:gamma signalling through PI3Kgamma
- Downstream signaling of activated FGFR
- Interferon alpha/beta signaling
- Signalling by NGF
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- ERK2 activation
- Regulation of IFNG signaling
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- Signaling by EGFR
- EGFR downregulation
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
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PPP2CA and APC |
protein phosphatase 2, catalytic subunit, alpha isozyme |
adenomatous polyposis coli |
- Signaling by GPCR
- Integration of energy metabolism
- Signaling by FGFR in disease
- Mitotic Prophase
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- ERKs are inactivated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Glycolysis
- Signaling by Wnt
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Degradation of beta-catenin by the destruction complex
- Toll Like Receptor 5 (TLR5) Cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- G1/S Transition
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Beta-catenin phosphorylation cascade
- Initiation of Nuclear Envelope Reformation
- Mitotic G1-G1/S phases
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Spry regulation of FGF signaling
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Toll Like Receptor 2 (TLR2) Cascade
- Platelet homeostasis
- deletions in the AMER1 gene destabilize the destruction complex
- Platelet sensitization by LDL
- AMER1 mutants destabilize the destruction complex
- Resolution of Sister Chromatid Cohesion
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Metabolism of carbohydrates
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
- PP2A-mediated dephosphorylation of key metabolic factors
- MASTL Facilitates Mitotic Progression
- Mitotic Prometaphase
- Costimulation by the CD28 family
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- G2/M Transition
- Mitotic Anaphase
- M Phase
- Toll Like Receptor TLR6:TLR2 Cascade
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- MyD88 cascade initiated on plasma membrane
- Cyclin A/B1 associated events during G2/M transition
- XAV939 inhibits tankyrase, stabilizing AXIN
- DARPP-32 events
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Nuclear Envelope Reassembly
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- E2F mediated regulation of DNA replication
- ERKs are inactivated
- Signalling by NGF
- MAP kinase activation in TLR cascade
- CTLA4 inhibitory signaling
- G1 Phase
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Toll Like Receptor 10 (TLR10) Cascade
- TCF dependent signaling in response to WNT
- ERK/MAPK targets
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by WNT in cancer
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Nuclear Events (kinase and transcription factor activation)
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- misspliced GSK3beta mutants stabilize beta-catenin
- APC truncation mutants have impaired AXIN binding
- T41 mutants of beta-catenin aren't phosphorylated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- Degradation of beta-catenin by the destruction complex
- RNF mutants show enhanced WNT signaling and proliferation
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- Programmed Cell Death
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- Apoptotic cleavage of cellular proteins
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Apoptotic execution phase
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- deletions in the AMER1 gene destabilize the destruction complex
- TCF dependent signaling in response to WNT
- AMER1 mutants destabilize the destruction complex
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
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PPP2CA and AXIN1 |
protein phosphatase 2, catalytic subunit, alpha isozyme |
axin 1 |
- Signaling by GPCR
- Integration of energy metabolism
- Signaling by FGFR in disease
- Mitotic Prophase
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- ERKs are inactivated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Glycolysis
- Signaling by Wnt
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Degradation of beta-catenin by the destruction complex
- Toll Like Receptor 5 (TLR5) Cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- G1/S Transition
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Beta-catenin phosphorylation cascade
- Initiation of Nuclear Envelope Reformation
- Mitotic G1-G1/S phases
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Spry regulation of FGF signaling
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Toll Like Receptor 2 (TLR2) Cascade
- Platelet homeostasis
- deletions in the AMER1 gene destabilize the destruction complex
- Platelet sensitization by LDL
- AMER1 mutants destabilize the destruction complex
- Resolution of Sister Chromatid Cohesion
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Metabolism of carbohydrates
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
- PP2A-mediated dephosphorylation of key metabolic factors
- MASTL Facilitates Mitotic Progression
- Mitotic Prometaphase
- Costimulation by the CD28 family
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- G2/M Transition
- Mitotic Anaphase
- M Phase
- Toll Like Receptor TLR6:TLR2 Cascade
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- MyD88 cascade initiated on plasma membrane
- Cyclin A/B1 associated events during G2/M transition
- XAV939 inhibits tankyrase, stabilizing AXIN
- DARPP-32 events
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Nuclear Envelope Reassembly
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- E2F mediated regulation of DNA replication
- ERKs are inactivated
- Signalling by NGF
- MAP kinase activation in TLR cascade
- CTLA4 inhibitory signaling
- G1 Phase
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Toll Like Receptor 10 (TLR10) Cascade
- TCF dependent signaling in response to WNT
- ERK/MAPK targets
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by WNT in cancer
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Nuclear Events (kinase and transcription factor activation)
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- misspliced GSK3beta mutants stabilize beta-catenin
- APC truncation mutants have impaired AXIN binding
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- Degradation of beta-catenin by the destruction complex
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- TCF dependent signaling in response to WNT
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- degradation of AXIN
- Signaling by WNT in cancer
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PPP2CA and PPP1CA |
protein phosphatase 2, catalytic subunit, alpha isozyme |
protein phosphatase 1, catalytic subunit, alpha isozyme |
- Signaling by GPCR
- Integration of energy metabolism
- Signaling by FGFR in disease
- Mitotic Prophase
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- ERKs are inactivated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Glycolysis
- Signaling by Wnt
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Degradation of beta-catenin by the destruction complex
- Toll Like Receptor 5 (TLR5) Cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- G1/S Transition
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Beta-catenin phosphorylation cascade
- Initiation of Nuclear Envelope Reformation
- Mitotic G1-G1/S phases
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Spry regulation of FGF signaling
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Toll Like Receptor 2 (TLR2) Cascade
- Platelet homeostasis
- deletions in the AMER1 gene destabilize the destruction complex
- Platelet sensitization by LDL
- AMER1 mutants destabilize the destruction complex
- Resolution of Sister Chromatid Cohesion
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Metabolism of carbohydrates
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
- PP2A-mediated dephosphorylation of key metabolic factors
- MASTL Facilitates Mitotic Progression
- Mitotic Prometaphase
- Costimulation by the CD28 family
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- G2/M Transition
- Mitotic Anaphase
- M Phase
- Toll Like Receptor TLR6:TLR2 Cascade
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- MyD88 cascade initiated on plasma membrane
- Cyclin A/B1 associated events during G2/M transition
- XAV939 inhibits tankyrase, stabilizing AXIN
- DARPP-32 events
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Nuclear Envelope Reassembly
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- E2F mediated regulation of DNA replication
- ERKs are inactivated
- Signalling by NGF
- MAP kinase activation in TLR cascade
- CTLA4 inhibitory signaling
- G1 Phase
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Toll Like Receptor 10 (TLR10) Cascade
- TCF dependent signaling in response to WNT
- ERK/MAPK targets
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by WNT in cancer
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Nuclear Events (kinase and transcription factor activation)
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- Loss of Function of TGFBR2 in Cancer
- Signaling by GPCR
- TGFBR2 MSI Frameshift Mutants in Cancer
- Metabolism of lipids and lipoproteins
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Opioid Signalling
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- DARPP-32 events
- SMAD4 MH2 Domain Mutants in Cancer
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PPP2CA and CAV1 |
protein phosphatase 2, catalytic subunit, alpha isozyme |
caveolin 1, caveolae protein, 22kDa |
- Signaling by GPCR
- Integration of energy metabolism
- Signaling by FGFR in disease
- Mitotic Prophase
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- ERKs are inactivated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Glycolysis
- Signaling by Wnt
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Degradation of beta-catenin by the destruction complex
- Toll Like Receptor 5 (TLR5) Cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- G1/S Transition
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Beta-catenin phosphorylation cascade
- Initiation of Nuclear Envelope Reformation
- Mitotic G1-G1/S phases
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Spry regulation of FGF signaling
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Toll Like Receptor 2 (TLR2) Cascade
- Platelet homeostasis
- deletions in the AMER1 gene destabilize the destruction complex
- Platelet sensitization by LDL
- AMER1 mutants destabilize the destruction complex
- Resolution of Sister Chromatid Cohesion
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Metabolism of carbohydrates
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
- PP2A-mediated dephosphorylation of key metabolic factors
- MASTL Facilitates Mitotic Progression
- Mitotic Prometaphase
- Costimulation by the CD28 family
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- G2/M Transition
- Mitotic Anaphase
- M Phase
- Toll Like Receptor TLR6:TLR2 Cascade
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- MyD88 cascade initiated on plasma membrane
- Cyclin A/B1 associated events during G2/M transition
- XAV939 inhibits tankyrase, stabilizing AXIN
- DARPP-32 events
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Nuclear Envelope Reassembly
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- E2F mediated regulation of DNA replication
- ERKs are inactivated
- Signalling by NGF
- MAP kinase activation in TLR cascade
- CTLA4 inhibitory signaling
- G1 Phase
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Toll Like Receptor 10 (TLR10) Cascade
- TCF dependent signaling in response to WNT
- ERK/MAPK targets
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by WNT in cancer
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Nuclear Events (kinase and transcription factor activation)
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- Metabolism of lipids and lipoproteins
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Lipid digestion, mobilization, and transport
- Signaling by Wnt
- Basigin interactions
- VEGFA-VEGFR2 Pathway
- Cell surface interactions at the vascular wall
- eNOS activation
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Metabolism of nitric oxide
- Signaling by VEGF
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- NOSTRIN mediated eNOS trafficking
- VEGFR2 mediated vascular permeability
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Signaling by WNT in cancer
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PPP2CA and PXN |
protein phosphatase 2, catalytic subunit, alpha isozyme |
paxillin |
- Signaling by GPCR
- Integration of energy metabolism
- Signaling by FGFR in disease
- Mitotic Prophase
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- ERKs are inactivated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Glycolysis
- Signaling by Wnt
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Degradation of beta-catenin by the destruction complex
- Toll Like Receptor 5 (TLR5) Cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- G1/S Transition
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Beta-catenin phosphorylation cascade
- Initiation of Nuclear Envelope Reformation
- Mitotic G1-G1/S phases
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Spry regulation of FGF signaling
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Toll Like Receptor 2 (TLR2) Cascade
- Platelet homeostasis
- deletions in the AMER1 gene destabilize the destruction complex
- Platelet sensitization by LDL
- AMER1 mutants destabilize the destruction complex
- Resolution of Sister Chromatid Cohesion
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Metabolism of carbohydrates
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
- PP2A-mediated dephosphorylation of key metabolic factors
- MASTL Facilitates Mitotic Progression
- Mitotic Prometaphase
- Costimulation by the CD28 family
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- G2/M Transition
- Mitotic Anaphase
- M Phase
- Toll Like Receptor TLR6:TLR2 Cascade
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- MyD88 cascade initiated on plasma membrane
- Cyclin A/B1 associated events during G2/M transition
- XAV939 inhibits tankyrase, stabilizing AXIN
- DARPP-32 events
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Nuclear Envelope Reassembly
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- E2F mediated regulation of DNA replication
- ERKs are inactivated
- Signalling by NGF
- MAP kinase activation in TLR cascade
- CTLA4 inhibitory signaling
- G1 Phase
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Toll Like Receptor 10 (TLR10) Cascade
- TCF dependent signaling in response to WNT
- ERK/MAPK targets
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by WNT in cancer
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Nuclear Events (kinase and transcription factor activation)
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- Cell junction organization
- GAB1 signalosome
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by EGFRvIII in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- VEGFA-VEGFR2 Pathway
- Signaling by EGFR
- Signaling by VEGF
- Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
- Signaling by EGFR in Cancer
- Localization of the PINCH-ILK-PARVIN complex to focal adhesions
- Cell-extracellular matrix interactions
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PPP2CA and DVL3 |
protein phosphatase 2, catalytic subunit, alpha isozyme |
dishevelled segment polarity protein 3 |
- Signaling by GPCR
- Integration of energy metabolism
- Signaling by FGFR in disease
- Mitotic Prophase
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- ERKs are inactivated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Glycolysis
- Signaling by Wnt
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Degradation of beta-catenin by the destruction complex
- Toll Like Receptor 5 (TLR5) Cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- G1/S Transition
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Beta-catenin phosphorylation cascade
- Initiation of Nuclear Envelope Reformation
- Mitotic G1-G1/S phases
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Spry regulation of FGF signaling
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Toll Like Receptor 2 (TLR2) Cascade
- Platelet homeostasis
- deletions in the AMER1 gene destabilize the destruction complex
- Platelet sensitization by LDL
- AMER1 mutants destabilize the destruction complex
- Resolution of Sister Chromatid Cohesion
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Metabolism of carbohydrates
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
- PP2A-mediated dephosphorylation of key metabolic factors
- MASTL Facilitates Mitotic Progression
- Mitotic Prometaphase
- Costimulation by the CD28 family
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- G2/M Transition
- Mitotic Anaphase
- M Phase
- Toll Like Receptor TLR6:TLR2 Cascade
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- MyD88 cascade initiated on plasma membrane
- Cyclin A/B1 associated events during G2/M transition
- XAV939 inhibits tankyrase, stabilizing AXIN
- DARPP-32 events
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Nuclear Envelope Reassembly
- Innate Immune System
- Nonsense-Mediated Decay (NMD)
- E2F mediated regulation of DNA replication
- ERKs are inactivated
- Signalling by NGF
- MAP kinase activation in TLR cascade
- CTLA4 inhibitory signaling
- G1 Phase
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Toll Like Receptor 10 (TLR10) Cascade
- TCF dependent signaling in response to WNT
- ERK/MAPK targets
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by WNT in cancer
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Nuclear Events (kinase and transcription factor activation)
|
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- WNT mediated activation of DVL
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- degradation of DVL
- negative regulation of TCF-dependent signaling by DVL-interacting proteins
- Signaling by Wnt
- Signaling by WNT in cancer
- PCP/CE pathway
- beta-catenin independent WNT signaling
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CREB1 and MYC |
cAMP responsive element binding protein 1 |
v-myc avian myelocytomatosis viral oncogene homolog |
- Signaling by the B Cell Receptor (BCR)
- Ca-dependent events
- Signaling by GPCR
- CaM pathway
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- NOTCH2 intracellular domain regulates transcription
- Signaling by SCF-KIT
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Signaling by NOTCH2
- PI3K/AKT activation
- Toll Like Receptor 5 (TLR5) Cascade
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- GAB1 signalosome
- Signaling by NOTCH
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- CREB phosphorylation through the activation of CaMKK
- AKT phosphorylates targets in the nucleus
- Calmodulin induced events
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Downstream signal transduction
- CREB phosphorylation through the activation of CaMKII
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- CREB phosphorylation
- Axon guidance
- PIP3 activates AKT signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- DAG and IP3 signaling
- Toll Like Receptor TLR6:TLR2 Cascade
- CaM pathway
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- PI3K events in ERBB2 signaling
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Downstream signaling of activated FGFR
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Post NMDA receptor activation events
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- MAP kinase activation in TLR cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- G-protein mediated events
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- PLC-gamma1 signalling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
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- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- binding of TCF/LEF:CTNNB1 to target gene promoters
- TGFBR1 LBD Mutants in Cancer
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Mitotic G1-G1/S phases
- FBXW7 Mutants and NOTCH1 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- S Phase
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Cyclin A:Cdk2-associated events at S phase entry
- Signaling by WNT in cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- SMAD4 MH2 Domain Mutants in Cancer
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- Adenosine monophosphate
- Naloxone
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PPP2CB and AXIN1 |
protein phosphatase 2, catalytic subunit, beta isozyme |
axin 1 |
- Signaling by GPCR
- Integration of energy metabolism
- Signaling by FGFR in disease
- Mitotic Prophase
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- ERKs are inactivated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Glycolysis
- Signaling by Wnt
- Glucose metabolism
- Toll Like Receptor TLR1:TLR2 Cascade
- Degradation of beta-catenin by the destruction complex
- Toll Like Receptor 5 (TLR5) Cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Myoclonic epilepsy of Lafora
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- G1/S Transition
- Glycogen storage diseases
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Beta-catenin phosphorylation cascade
- Mitotic G1-G1/S phases
- ERK/MAPK targets
- Negative regulation of FGFR signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Spry regulation of FGF signaling
- Toll Like Receptor 2 (TLR2) Cascade
- Platelet homeostasis
- deletions in the AMER1 gene destabilize the destruction complex
- Platelet sensitization by LDL
- AMER1 mutants destabilize the destruction complex
- Resolution of Sister Chromatid Cohesion
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Metabolism of carbohydrates
- Mitotic G2-G2/M phases
- Mitotic Metaphase and Anaphase
- Adaptive Immune System
- PP2A-mediated dephosphorylation of key metabolic factors
- MASTL Facilitates Mitotic Progression
- Mitotic Prometaphase
- Costimulation by the CD28 family
- Separation of Sister Chromatids
- APC truncation mutants have impaired AXIN binding
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- G2/M Transition
- Mitotic Anaphase
- Toll Like Receptor TLR6:TLR2 Cascade
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Activated TLR4 signalling
- S37 mutants of beta-catenin aren't phosphorylated
- MyD88 cascade initiated on plasma membrane
- Cyclin A/B1 associated events during G2/M transition
- XAV939 inhibits tankyrase, stabilizing AXIN
- DARPP-32 events
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Innate Immune System
- E2F mediated regulation of DNA replication
- ERKs are inactivated
- Signalling by NGF
- MAP kinase activation in TLR cascade
- CTLA4 inhibitory signaling
- G1 Phase
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Cell Cycle, Mitotic
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Cyclin D associated events in G1
- Toll Like Receptor 10 (TLR10) Cascade
- TCF dependent signaling in response to WNT
- ERK/MAPK targets
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Signaling by WNT in cancer
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Nuclear Events (kinase and transcription factor activation)
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- misspliced GSK3beta mutants stabilize beta-catenin
- APC truncation mutants have impaired AXIN binding
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- Degradation of beta-catenin by the destruction complex
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- TCF dependent signaling in response to WNT
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- degradation of AXIN
- Signaling by WNT in cancer
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CREB1 and PPP1CA |
cAMP responsive element binding protein 1 |
protein phosphatase 1, catalytic subunit, alpha isozyme |
- Signaling by the B Cell Receptor (BCR)
- Ca-dependent events
- Signaling by GPCR
- CaM pathway
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- NOTCH2 intracellular domain regulates transcription
- Signaling by SCF-KIT
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Signaling by NOTCH2
- PI3K/AKT activation
- Toll Like Receptor 5 (TLR5) Cascade
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- GAB1 signalosome
- Signaling by NOTCH
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- CREB phosphorylation through the activation of CaMKK
- AKT phosphorylates targets in the nucleus
- Calmodulin induced events
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Downstream signal transduction
- CREB phosphorylation through the activation of CaMKII
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- CREB phosphorylation
- Axon guidance
- PIP3 activates AKT signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- DAG and IP3 signaling
- Toll Like Receptor TLR6:TLR2 Cascade
- CaM pathway
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- PI3K events in ERBB2 signaling
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Downstream signaling of activated FGFR
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Post NMDA receptor activation events
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- MAP kinase activation in TLR cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- G-protein mediated events
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- PLC-gamma1 signalling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
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- Loss of Function of TGFBR2 in Cancer
- Signaling by GPCR
- TGFBR2 MSI Frameshift Mutants in Cancer
- Metabolism of lipids and lipoproteins
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Opioid Signalling
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- DARPP-32 events
- SMAD4 MH2 Domain Mutants in Cancer
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- Adenosine monophosphate
- Naloxone
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CREB1 and KAT5 |
cAMP responsive element binding protein 1 |
K(lysine) acetyltransferase 5 |
- Signaling by the B Cell Receptor (BCR)
- Ca-dependent events
- Signaling by GPCR
- CaM pathway
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- NOTCH2 intracellular domain regulates transcription
- Signaling by SCF-KIT
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Signaling by NOTCH2
- PI3K/AKT activation
- Toll Like Receptor 5 (TLR5) Cascade
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- GAB1 signalosome
- Signaling by NOTCH
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- CREB phosphorylation through the activation of CaMKK
- AKT phosphorylates targets in the nucleus
- Calmodulin induced events
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Downstream signal transduction
- CREB phosphorylation through the activation of CaMKII
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- CREB phosphorylation
- Axon guidance
- PIP3 activates AKT signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- DAG and IP3 signaling
- Toll Like Receptor TLR6:TLR2 Cascade
- CaM pathway
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- PI3K events in ERBB2 signaling
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Downstream signaling of activated FGFR
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Post NMDA receptor activation events
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- MAP kinase activation in TLR cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- G-protein mediated events
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- PLC-gamma1 signalling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
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- Chromatin modifying enzymes
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- HATs acetylate histones
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- Adenosine monophosphate
- Naloxone
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CREB1 and SMARCA4 |
cAMP responsive element binding protein 1 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
- Signaling by the B Cell Receptor (BCR)
- Ca-dependent events
- Signaling by GPCR
- CaM pathway
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- NOTCH2 intracellular domain regulates transcription
- Signaling by SCF-KIT
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Signaling by NOTCH2
- PI3K/AKT activation
- Toll Like Receptor 5 (TLR5) Cascade
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- GAB1 signalosome
- Signaling by NOTCH
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- CREB phosphorylation through the activation of CaMKK
- AKT phosphorylates targets in the nucleus
- Calmodulin induced events
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Downstream signal transduction
- CREB phosphorylation through the activation of CaMKII
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- CREB phosphorylation
- Axon guidance
- PIP3 activates AKT signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- DAG and IP3 signaling
- Toll Like Receptor TLR6:TLR2 Cascade
- CaM pathway
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- PI3K events in ERBB2 signaling
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Downstream signaling of activated FGFR
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Post NMDA receptor activation events
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- MAP kinase activation in TLR cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- G-protein mediated events
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- PLC-gamma1 signalling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
|
- Chromatin modifying enzymes
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- formation of the beta-catenin:TCF transactivating complex
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- RMTs methylate histone arginines
|
- Adenosine monophosphate
- Naloxone
|
|
|
|
CREB1 and CHD8 |
cAMP responsive element binding protein 1 |
chromodomain helicase DNA binding protein 8 |
- Signaling by the B Cell Receptor (BCR)
- Ca-dependent events
- Signaling by GPCR
- CaM pathway
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- NOTCH2 intracellular domain regulates transcription
- Signaling by SCF-KIT
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Signaling by NOTCH2
- PI3K/AKT activation
- Toll Like Receptor 5 (TLR5) Cascade
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- GAB1 signalosome
- Signaling by NOTCH
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- CREB phosphorylation through the activation of CaMKK
- AKT phosphorylates targets in the nucleus
- Calmodulin induced events
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Downstream signal transduction
- CREB phosphorylation through the activation of CaMKII
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- CREB phosphorylation
- Axon guidance
- PIP3 activates AKT signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- DAG and IP3 signaling
- Toll Like Receptor TLR6:TLR2 Cascade
- CaM pathway
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- PI3K events in ERBB2 signaling
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Downstream signaling of activated FGFR
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Post NMDA receptor activation events
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- MAP kinase activation in TLR cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- G-protein mediated events
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- PLC-gamma1 signalling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
|
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Wnt
- Signaling by WNT in cancer
- deactivation of the beta-catenin transactivating complex
|
- Adenosine monophosphate
- Naloxone
|
|
|
|
CREB1 and CCDC6 |
cAMP responsive element binding protein 1 |
coiled-coil domain containing 6 |
- Signaling by the B Cell Receptor (BCR)
- Ca-dependent events
- Signaling by GPCR
- CaM pathway
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- NOTCH2 intracellular domain regulates transcription
- Signaling by SCF-KIT
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Signaling by NOTCH2
- PI3K/AKT activation
- Toll Like Receptor 5 (TLR5) Cascade
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- GAB1 signalosome
- Signaling by NOTCH
- TRIF-mediated TLR3/TLR4 signaling
- Opioid Signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- CREB phosphorylation through the activation of CaMKK
- AKT phosphorylates targets in the nucleus
- Calmodulin induced events
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Downstream signal transduction
- CREB phosphorylation through the activation of CaMKII
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- CREB phosphorylation
- Axon guidance
- PIP3 activates AKT signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- DAG and IP3 signaling
- Toll Like Receptor TLR6:TLR2 Cascade
- CaM pathway
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- PI3K events in ERBB2 signaling
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Downstream signaling of activated FGFR
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- Post NMDA receptor activation events
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- MAP kinase activation in TLR cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- G-protein mediated events
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- Signaling by FGFR
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- PLC-gamma1 signalling
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
|
|
- Adenosine monophosphate
- Naloxone
|
|
|
|
MAP2K1 and MYC |
mitogen-activated protein kinase kinase 1 |
v-myc avian myelocytomatosis viral oncogene homolog |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- DAP12 signaling
- Uptake and actions of bacterial toxins
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- SOS-mediated signalling
- Uptake and function of anthrax toxins
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- ERK1 activation
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-1 signaling
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Axon guidance
- IRS-mediated signalling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- L1CAM interactions
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- ERK activation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Insulin receptor signalling cascade
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- binding of TCF/LEF:CTNNB1 to target gene promoters
- TGFBR1 LBD Mutants in Cancer
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Mitotic G1-G1/S phases
- FBXW7 Mutants and NOTCH1 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- S Phase
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Cyclin A:Cdk2-associated events at S phase entry
- Signaling by WNT in cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- SMAD4 MH2 Domain Mutants in Cancer
|
- K-252a
- 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
|
|
|
|
MAP2K1 and PRKCZ |
mitogen-activated protein kinase kinase 1 |
protein kinase C, zeta |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- DAP12 signaling
- Uptake and actions of bacterial toxins
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- SOS-mediated signalling
- Uptake and function of anthrax toxins
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- ERK1 activation
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-1 signaling
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Axon guidance
- IRS-mediated signalling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- L1CAM interactions
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- ERK activation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Insulin receptor signalling cascade
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
- Loss of Function of TGFBR2 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- VEGFA-VEGFR2 Pathway
- VEGFR2 mediated cell proliferation
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by VEGF
- GPVI-mediated activation cascade
- Platelet activation, signaling and aggregation
- SMAD4 MH2 Domain Mutants in Cancer
|
- K-252a
- 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
|
|
|
|
MAP2K1 and BRAF |
mitogen-activated protein kinase kinase 1 |
B-Raf proto-oncogene, serine/threonine kinase |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- DAP12 signaling
- Uptake and actions of bacterial toxins
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- SOS-mediated signalling
- Uptake and function of anthrax toxins
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- ERK1 activation
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-1 signaling
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Axon guidance
- IRS-mediated signalling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- L1CAM interactions
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- ERK activation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Insulin receptor signalling cascade
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
- Signalling to ERKs
- Prolonged ERK activation events
- Signalling by NGF
- Signaling by FGFR in disease
- NGF signalling via TRKA from the plasma membrane
- Spry regulation of FGF signaling
- CREB phosphorylation through the activation of Ras
- Signaling by FGFR
- ARMS-mediated activation
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signalling to p38 via RIT and RIN
- Frs2-mediated activation
- Transmission across Chemical Synapses
- Post NMDA receptor activation events
- Negative regulation of FGFR signaling
|
- K-252a
- 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide
- Bosutinib
- (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide
- 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide
- N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
- 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
- Trametinib
|
- Sorafenib
- N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
- N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide
- (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime
- Vemurafenib
- Regorafenib
- Dabrafenib
|
|
|
MAP2K2 and BRAF |
mitogen-activated protein kinase kinase 2 |
B-Raf proto-oncogene, serine/threonine kinase |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- DAP12 signaling
- Uptake and actions of bacterial toxins
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- SOS-mediated signalling
- Uptake and function of anthrax toxins
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- TRIF-mediated TLR3/TLR4 signaling
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- ERK activation
- Axon guidance
- IRS-mediated signalling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- L1CAM interactions
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- ERK activation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Insulin receptor signalling cascade
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- MyD88-independent cascade
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- ERK2 activation
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- ERK2 activation
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- Signalling to ERKs
- Prolonged ERK activation events
- Signalling by NGF
- Signaling by FGFR in disease
- NGF signalling via TRKA from the plasma membrane
- Spry regulation of FGF signaling
- CREB phosphorylation through the activation of Ras
- Signaling by FGFR
- ARMS-mediated activation
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signalling to p38 via RIT and RIN
- Frs2-mediated activation
- Transmission across Chemical Synapses
- Post NMDA receptor activation events
- Negative regulation of FGFR signaling
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- Sorafenib
- N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
- N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide
- (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime
- Vemurafenib
- Regorafenib
- Dabrafenib
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TYK2 and STAM2 |
tyrosine kinase 2 |
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 |
- Signaling by GPCR
- Signaling by FGFR in disease
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Toll Like Receptor TLR1:TLR2 Cascade
- DAP12 signaling
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- SOS-mediated signalling
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- Regulation of IFNA signaling
- TRIF-mediated TLR3/TLR4 signaling
- SHC-related events triggered by IGF1R
- ERK1 activation
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- ERK1 activation
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Downstream signal transduction
- Signalling to RAS
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- ERK activation
- IRS-mediated signalling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Interleukin-6 signaling
- IGF1R signaling cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- ERK activation
- Downstream signaling of activated FGFR
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Interferon alpha/beta signaling
- NCAM signaling for neurite out-growth
- Signalling to p38 via RIT and RIN
- RAF/MAP kinase cascade
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Interferon Signaling
- IRS-related events
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- SHC-related events
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- ERK2 activation
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- SHC1 events in EGFR signaling
- Toll Like Receptor 10 (TLR10) Cascade
- FRS2-mediated cascade
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- ERK2 activation
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- Signaling by EGFR
- EGFR downregulation
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
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