PAK1 and ARHGEF7 |
p21 protein (Cdc42/Rac)-activated kinase 1 |
Rho guanine nucleotide exchange factor (GEF) 7 |
- Axon guidance
- Costimulation by the CD28 family
- FCERI mediated MAPK activation
- L1CAM interactions
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Ephrin signaling
- Activation of Rac
- VEGFR2 mediated vascular permeability
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
- Generation of second messenger molecules
- Signal transduction by L1
- Semaphorin interactions
- CD28 co-stimulation
- CD28 dependent Vav1 pathway
- TCR signaling
- DSCAM interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Fc epsilon receptor (FCERI) signaling
- Signaling by Robo receptor
- Adaptive Immune System
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- EGFR downregulation
- Signaling by GPCR
- Signalling by NGF
- Axon guidance
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- p75 NTR receptor-mediated signalling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Rho GTPase cycle
- Signaling by EGFR
- GPCR downstream signaling
- Ephrin signaling
- NRAGE signals death through JNK
- Signaling by Rho GTPases
- Signaling by EGFR in Cancer
- EPH-Ephrin signaling
- G alpha (12/13) signalling events
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PAK2 and ARHGEF7 |
p21 protein (Cdc42/Rac)-activated kinase 2 |
Rho guanine nucleotide exchange factor (GEF) 7 |
- Regulation of PAK-2p34 activity by PS-GAP/RHG10
- Costimulation by the CD28 family
- Axon guidance
- HIV Infection
- FCERI mediated MAPK activation
- VEGFA-VEGFR2 Pathway
- Nef and signal transduction
- Ephrin signaling
- Activation of Rac
- VEGFR2 mediated vascular permeability
- Programmed Cell Death
- EPH-Ephrin signaling
- Innate Immune System
- Generation of second messenger molecules
- Semaphorin interactions
- Apoptotic execution phase
- CD28 co-stimulation
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Host Interactions of HIV factors
- The role of Nef in HIV-1 replication and disease pathogenesis
- CD28 dependent Vav1 pathway
- Stimulation of the cell death response by PAK-2p34
- TCR signaling
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Fc epsilon receptor (FCERI) signaling
- Signaling by Robo receptor
- Regulation of Apoptosis
- Adaptive Immune System
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- EGFR downregulation
- Signaling by GPCR
- Signalling by NGF
- Axon guidance
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- p75 NTR receptor-mediated signalling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Rho GTPase cycle
- Signaling by EGFR
- GPCR downstream signaling
- Ephrin signaling
- NRAGE signals death through JNK
- Signaling by Rho GTPases
- Signaling by EGFR in Cancer
- EPH-Ephrin signaling
- G alpha (12/13) signalling events
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RAC1 and ARHGEF7 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
Rho guanine nucleotide exchange factor (GEF) 7 |
- Signaling by GPCR
- DCC mediated attractive signaling
- FCERI mediated MAPK activation
- Signaling by Wnt
- Nef and signal transduction
- Signaling by SCF-KIT
- DAP12 signaling
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Sema4D induced cell migration and growth-cone collapse
- DAP12 interactions
- Host Interactions of HIV factors
- CD28 co-stimulation
- The role of Nef in HIV-1 replication and disease pathogenesis
- Factors involved in megakaryocyte development and platelet production
- GPCR downstream signaling
- Signaling by VEGF
- Fc epsilon receptor (FCERI) signaling
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- Platelet activation, signaling and aggregation
- PCP/CE pathway
- Adaptive Immune System
- Axon guidance
- Costimulation by the CD28 family
- HIV Infection
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Inactivation of Cdc42 and Rac
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
- Activation of Rac
- VEGFR2 mediated vascular permeability
- Sema4D mediated inhibition of cell attachment and migration
- G alpha (12/13) signalling events
- Sema4D in semaphorin signaling
- Netrin-1 signaling
- Innate Immune System
- Signalling by NGF
- Signal transduction by L1
- Cell death signalling via NRAGE, NRIF and NADE
- Semaphorin interactions
- p75 NTR receptor-mediated signalling
- beta-catenin independent WNT signaling
- CD28 dependent Vav1 pathway
- DSCAM interactions
- NRAGE signals death through JNK
- GPVI-mediated activation cascade
- Signaling by Robo receptor
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- EGFR downregulation
- Signaling by GPCR
- Signalling by NGF
- Axon guidance
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- p75 NTR receptor-mediated signalling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Rho GTPase cycle
- Signaling by EGFR
- GPCR downstream signaling
- Ephrin signaling
- NRAGE signals death through JNK
- Signaling by Rho GTPases
- Signaling by EGFR in Cancer
- EPH-Ephrin signaling
- G alpha (12/13) signalling events
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- Guanosine-5\'-Diphosphate
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WAS and ARHGEF7 |
Wiskott-Aldrich syndrome |
Rho guanine nucleotide exchange factor (GEF) 7 |
- TCR signaling
- Generation of second messenger molecules
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
- Adaptive Immune System
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- EGFR downregulation
- Signaling by GPCR
- Signalling by NGF
- Axon guidance
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- p75 NTR receptor-mediated signalling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Rho GTPase cycle
- Signaling by EGFR
- GPCR downstream signaling
- Ephrin signaling
- NRAGE signals death through JNK
- Signaling by Rho GTPases
- Signaling by EGFR in Cancer
- EPH-Ephrin signaling
- G alpha (12/13) signalling events
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ABL1 and BRCA1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
breast cancer 1, early onset |
- Role of Abl in Robo-Slit signaling
- CDO in myogenesis
- Axon guidance
- Myogenesis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Factors involved in megakaryocyte development and platelet production
- Signaling by Robo receptor
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
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- ATM mediated phosphorylation of repair proteins
- Meiotic recombination
- Fanconi Anemia pathway
- ATM mediated response to DNA double-strand break
- Homologous Recombination Repair
- Meiotic synapsis
- Homologous recombination repair of replication-independent double-strand breaks
- Recruitment of repair and signaling proteins to double-strand breaks
- Double-Strand Break Repair
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- Adenosine triphosphate
- Imatinib
- Dasatinib
- N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
- Nilotinib
- Bosutinib
- 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
- MYRISTIC ACID
- 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
- 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
- 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
- Regorafenib
- Ponatinib
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ATF1 and BRCA1 |
activating transcription factor 1 |
breast cancer 1, early onset |
- CREB phosphorylation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- CREB phosphorylation
- Toll Like Receptor TLR6:TLR2 Cascade
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- MAP kinase activation in TLR cascade
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
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- ATM mediated phosphorylation of repair proteins
- Meiotic recombination
- Fanconi Anemia pathway
- ATM mediated response to DNA double-strand break
- Homologous Recombination Repair
- Meiotic synapsis
- Homologous recombination repair of replication-independent double-strand breaks
- Recruitment of repair and signaling proteins to double-strand breaks
- Double-Strand Break Repair
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CBLB and ARHGEF7 |
Cbl proto-oncogene B, E3 ubiquitin protein ligase |
Rho guanine nucleotide exchange factor (GEF) 7 |
- Signaling by the B Cell Receptor (BCR)
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Adaptive Immune System
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- EGFR downregulation
- Signaling by GPCR
- Signalling by NGF
- Axon guidance
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- p75 NTR receptor-mediated signalling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Rho GTPase cycle
- Signaling by EGFR
- GPCR downstream signaling
- Ephrin signaling
- NRAGE signals death through JNK
- Signaling by Rho GTPases
- Signaling by EGFR in Cancer
- EPH-Ephrin signaling
- G alpha (12/13) signalling events
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DNM2 and EPS15 |
dynamin 2 |
epidermal growth factor receptor pathway substrate 15 |
- Retrograde neurotrophin signalling
- Axon guidance
- Gap junction degradation
- Golgi Associated Vesicle Biogenesis
- L1CAM interactions
- Recycling pathway of L1
- Clathrin derived vesicle budding
- Lysosome Vesicle Biogenesis
- Metabolism of nitric oxide
- Gap junction trafficking and regulation
- NOSTRIN mediated eNOS trafficking
- MHC class II antigen presentation
- eNOS activation and regulation
- trans-Golgi Network Vesicle Budding
- Innate Immune System
- Formation of annular gap junctions
- Signalling by NGF
- Gap junction trafficking
- NGF signalling via TRKA from the plasma membrane
- Toll-Like Receptors Cascades
- Toll Like Receptor 4 (TLR4) Cascade
- Adaptive Immune System
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- Signaling by EGFR
- EGFR downregulation
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
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PAK3 and PXN |
p21 protein (Cdc42/Rac)-activated kinase 3 |
paxillin |
- Generation of second messenger molecules
- Costimulation by the CD28 family
- Axon guidance
- Semaphorin interactions
- CD28 co-stimulation
- FCERI mediated MAPK activation
- VEGFA-VEGFR2 Pathway
- CD28 dependent Vav1 pathway
- Ephrin signaling
- TCR signaling
- Activation of Rac
- Signaling by VEGF
- VEGFR2 mediated vascular permeability
- EPH-Ephrin signaling
- Fc epsilon receptor (FCERI) signaling
- Sema3A PAK dependent Axon repulsion
- Signaling by Robo receptor
- Innate Immune System
- Adaptive Immune System
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- Cell junction organization
- GAB1 signalosome
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by EGFRvIII in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- VEGFA-VEGFR2 Pathway
- Signaling by EGFR
- Signaling by VEGF
- Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
- Signaling by EGFR in Cancer
- Localization of the PINCH-ILK-PARVIN complex to focal adhesions
- Cell-extracellular matrix interactions
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PAK3 and ARHGEF7 |
p21 protein (Cdc42/Rac)-activated kinase 3 |
Rho guanine nucleotide exchange factor (GEF) 7 |
- Generation of second messenger molecules
- Costimulation by the CD28 family
- Axon guidance
- Semaphorin interactions
- CD28 co-stimulation
- FCERI mediated MAPK activation
- VEGFA-VEGFR2 Pathway
- CD28 dependent Vav1 pathway
- Ephrin signaling
- TCR signaling
- Activation of Rac
- Signaling by VEGF
- VEGFR2 mediated vascular permeability
- EPH-Ephrin signaling
- Fc epsilon receptor (FCERI) signaling
- Sema3A PAK dependent Axon repulsion
- Signaling by Robo receptor
- Innate Immune System
- Adaptive Immune System
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- EGFR downregulation
- Signaling by GPCR
- Signalling by NGF
- Axon guidance
- Cell death signalling via NRAGE, NRIF and NADE
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- p75 NTR receptor-mediated signalling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Rho GTPase cycle
- Signaling by EGFR
- GPCR downstream signaling
- Ephrin signaling
- NRAGE signals death through JNK
- Signaling by Rho GTPases
- Signaling by EGFR in Cancer
- EPH-Ephrin signaling
- G alpha (12/13) signalling events
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RAP1B and TLE1 |
RAP1B, member of RAS oncogene family |
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
- Rap1 signalling
- p130Cas linkage to MAPK signaling for integrins
- Integrin alphaIIb beta3 signaling
- GRB2:SOS provides linkage to MAPK signaling for Integrins
- Platelet activation, signaling and aggregation
- Platelet Aggregation (Plug Formation)
- Adaptive Immune System
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- APC truncation mutants have impaired AXIN binding
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- S37 mutants of beta-catenin aren't phosphorylated
- Degradation of beta-catenin by the destruction complex
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- RNF mutants show enhanced WNT signaling and proliferation
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by NOTCH1 in Cancer
- truncations of AMER1 destabilize the destruction complex
- FBXW7 Mutants and NOTCH1 in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- repression of WNT target genes
- NOTCH1 Intracellular Domain Regulates Transcription
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- TCF dependent signaling in response to WNT
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by WNT in cancer
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ACTG1 and BRCA1 |
actin gamma 1 |
breast cancer 1, early onset |
- Axon guidance
- Gap junction degradation
- Adherens junctions interactions
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- Recycling pathway of L1
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Interaction between L1 and Ankyrins
- Cell-cell junction organization
- EPH-ephrin mediated repulsion of cells
- Gap junction trafficking and regulation
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
- Cell junction organization
- Formation of annular gap junctions
- Gap junction trafficking
- Signaling by VEGF
- Cell-extracellular matrix interactions
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- ATM mediated phosphorylation of repair proteins
- Meiotic recombination
- Fanconi Anemia pathway
- ATM mediated response to DNA double-strand break
- Homologous Recombination Repair
- Meiotic synapsis
- Homologous recombination repair of replication-independent double-strand breaks
- Recruitment of repair and signaling proteins to double-strand breaks
- Double-Strand Break Repair
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CAMK2D and HDAC4 |
calcium/calmodulin-dependent protein kinase II delta |
histone deacetylase 4 |
- Interferon Signaling
- Cytokine Signaling in Immune system
- Cellular response to heat stress
- CREB phosphorylation through the activation of Ras
- Trafficking of AMPA receptors
- Interferon gamma signaling
- HSF1-dependent transactivation
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Unblocking of NMDA receptor, glutamate binding and activation
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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CDC34 and HIF1A |
cell division cycle 34 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
- Antigen processing: Ubiquitination & Proteasome degradation
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Cellular response to hypoxia
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Signaling by NOTCH
- Regulation of gene expression by Hypoxia-inducible Factor
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- FBXW7 Mutants and NOTCH1 in Cancer
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KPNA2 and SPRY1 |
karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
sprouty homolog 1, antagonist of FGF signaling (Drosophila) |
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
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- Signaling by EGFR
- EGFR downregulation
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
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PSMA3 and FRAT1 |
proteasome (prosome, macropain) subunit, alpha type, 3 |
frequently rearranged in advanced T-cell lymphomas 1 |
- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- Hh ligand biogenesis disease
- T41 mutants of beta-catenin aren't phosphorylated
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- Stabilization of p53
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Regulation of mRNA stability by proteins that bind AU-rich elements
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- DNA Replication Pre-Initiation
- S45 mutants of beta-catenin aren't phosphorylated
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- deletions in the AMER1 gene destabilize the destruction complex
- Autodegradation of the E3 ubiquitin ligase COP1
- AMER1 mutants destabilize the destruction complex
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- PCP/CE pathway
- Adaptive Immune System
- CDK-mediated phosphorylation and removal of Cdc6
- Hedgehog ligand biogenesis
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Separation of Sister Chromatids
- HIV Infection
- Ubiquitin-dependent degradation of Cyclin D
- APC truncation mutants have impaired AXIN binding
- Assembly of the pre-replicative complex
- Autodegradation of Cdh1 by Cdh1:APC/C
- p53-Dependent G1 DNA Damage Response
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- p53-Independent DNA Damage Response
- p53-Independent G1/S DNA damage checkpoint
- G1/S DNA Damage Checkpoints
- Vpu mediated degradation of CD4
- Synthesis of DNA
- M/G1 Transition
- Ubiquitin-dependent degradation of Cyclin D1
- TCF dependent signaling in response to WNT
- SCF-beta-TrCP mediated degradation of Emi1
- degradation of AXIN
- Signaling by Hedgehog
- Regulation of mitotic cell cycle
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Cell Cycle Checkpoints
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Regulation of Apoptosis
- Degradation of GLI2 by the proteasome
- Signaling by the B Cell Receptor (BCR)
- Vif-mediated degradation of APOBEC3G
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- p53-Dependent G1/S DNA damage checkpoint
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- APC/C:Cdc20 mediated degradation of Securin
- AUF1 (hnRNP D0) destabilizes mRNA
- CDK-mediated phosphorylation and removal of Cdc6
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- truncations of AMER1 destabilize the destruction complex
- Processing-defective Hh variants abrogate ligand secretion
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- AXIN missense mutants destabilize the destruction complex
- S Phase
- APC/C-mediated degradation of cell cycle proteins
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Mitotic Metaphase and Anaphase
- Regulation of ornithine decarboxylase (ODC)
- Antigen processing: Ubiquitination & Proteasome degradation
- Orc1 removal from chromatin
- Mitotic Anaphase
- M Phase
- APC truncation mutants are not K63 polyubiquitinated
- Metabolism of amino acids and derivatives
- Hedgehog 'on' state
- Programmed Cell Death
- Class I MHC mediated antigen processing & presentation
- Regulation of DNA replication
- Cell Cycle, Mitotic
- beta-catenin independent WNT signaling
- Orc1 removal from chromatin
- Activation of NF-kappaB in B cells
- Asymmetric localization of PCP proteins
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Cross-presentation of soluble exogenous antigens (endosomes)
- Antigen processing-Cross presentation
- CDT1 association with the CDC6:ORC:origin complex
- ER-Phagosome pathway
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- misspliced GSK3beta mutants stabilize beta-catenin
- APC truncation mutants have impaired AXIN binding
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- Degradation of beta-catenin by the destruction complex
- RNF mutants show enhanced WNT signaling and proliferation
- S33 mutants of beta-catenin aren't phosphorylated
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- XAV939 inhibits tankyrase, stabilizing AXIN
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- deletions in the AMER1 gene destabilize the destruction complex
- TCF dependent signaling in response to WNT
- AMER1 mutants destabilize the destruction complex
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
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CRK and NTRK1 |
v-crk avian sarcoma virus CT10 oncogene homolog |
neurotrophic tyrosine kinase, receptor, type 1 |
- Signalling to ERKs
- Prolonged ERK activation events
- Platelet Aggregation (Plug Formation)
- VEGFA-VEGFR2 Pathway
- Regulation of signaling by CBL
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Signaling by Insulin receptor
- Innate Immune System
- Signaling by PDGF
- Signalling by NGF
- Insulin receptor signalling cascade
- p130Cas linkage to MAPK signaling for integrins
- Integrin alphaIIb beta3 signaling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- ARMS-mediated activation
- Signaling by Interleukins
- Signal attenuation
- Signaling by VEGF
- Downstream signal transduction
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Retrograde neurotrophin signalling
- Signalling to ERKs
- Signalling by NGF
- Prolonged ERK activation events
- Activation of TRKA receptors
- NGF signalling via TRKA from the plasma membrane
- ARMS-mediated activation
- TRKA activation by NGF
- PI3K/AKT activation
- Signalling to RAS
- Signalling to STAT3
- NGF-independant TRKA activation
- PLC-gamma1 signalling
- Signalling to p38 via RIT and RIN
- Frs2-mediated activation
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- Amitriptyline
- Imatinib
- Regorafenib
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CRK and RET |
v-crk avian sarcoma virus CT10 oncogene homolog |
ret proto-oncogene |
- Signalling to ERKs
- Prolonged ERK activation events
- Platelet Aggregation (Plug Formation)
- VEGFA-VEGFR2 Pathway
- Regulation of signaling by CBL
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Signaling by Insulin receptor
- Innate Immune System
- Signaling by PDGF
- Signalling by NGF
- Insulin receptor signalling cascade
- p130Cas linkage to MAPK signaling for integrins
- Integrin alphaIIb beta3 signaling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- ARMS-mediated activation
- Signaling by Interleukins
- Signal attenuation
- Signaling by VEGF
- Downstream signal transduction
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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CRK and BCAR1 |
v-crk avian sarcoma virus CT10 oncogene homolog |
breast cancer anti-estrogen resistance 1 |
- Signalling to ERKs
- Prolonged ERK activation events
- Platelet Aggregation (Plug Formation)
- VEGFA-VEGFR2 Pathway
- Regulation of signaling by CBL
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Signaling by Insulin receptor
- Innate Immune System
- Signaling by PDGF
- Signalling by NGF
- Insulin receptor signalling cascade
- p130Cas linkage to MAPK signaling for integrins
- Integrin alphaIIb beta3 signaling
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- ARMS-mediated activation
- Signaling by Interleukins
- Signal attenuation
- Signaling by VEGF
- Downstream signal transduction
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Signaling by PDGF
- Signaling by VEGF
- Downstream signal transduction
- p130Cas linkage to MAPK signaling for integrins
- Integrin alphaIIb beta3 signaling
- Platelet activation, signaling and aggregation
- Platelet Aggregation (Plug Formation)
- VEGFA-VEGFR2 Pathway
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ACTB and H2AFX |
actin, beta |
H2A histone family, member X |
- Axon guidance
- Gap junction degradation
- Adherens junctions interactions
- Translocation of GLUT4 to the plasma membrane
- L1CAM interactions
- Recycling pathway of L1
- HATs acetylate histones
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- Interaction between L1 and Ankyrins
- Cell-cell junction organization
- EPH-ephrin mediated repulsion of cells
- Prefoldin mediated transfer of substrate to CCT/TriC
- Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
- Gap junction trafficking and regulation
- EPH-Ephrin signaling
- Fcgamma receptor (FCGR) dependent phagocytosis
- Regulation of actin dynamics for phagocytic cup formation
- Folding of actin by CCT/TriC
- Innate Immune System
- Cell junction organization
- Protein folding
- Formation of annular gap junctions
- Chromatin organization
- Gap junction trafficking
- Factors involved in megakaryocyte development and platelet production
- Chromatin modifying enzymes
- Signaling by VEGF
- Chaperonin-mediated protein folding
- Cell-extracellular matrix interactions
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- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Mitotic Prophase
- Regulatory RNA pathways
- Deposition of new CENPA-containing nucleosomes at the centromere
- Cellular Senescence
- Signaling by Wnt
- Amyloids
- NoRC negatively regulates rRNA expression
- Packaging Of Telomere Ends
- RNF mutants show enhanced WNT signaling and proliferation
- Homologous recombination repair of replication-independent double-strand breaks
- ATM mediated phosphorylation of repair proteins
- DNA Damage/Telomere Stress Induced Senescence
- Chromosome Maintenance
- ATM mediated response to DNA double-strand break
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Chromatin organization
- formation of the beta-catenin:TCF transactivating complex
- Meiotic synapsis
- Senescence-Associated Secretory Phenotype (SASP)
- Chromatin modifying enzymes
- Recruitment of repair and signaling proteins to double-strand breaks
- SIRT1 negatively regulates rRNA Expression
- Condensation of Prophase Chromosomes
- MRN complex relocalizes to nuclear foci
- RNA Polymerase I Promoter Clearance
- Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
- M Phase
- Telomere Maintenance
- Nucleosome assembly
- XAV939 inhibits tankyrase, stabilizing AXIN
- Double-Strand Break Repair
- DNA methylation
- Transcriptional regulation by small RNAs
- Meiotic recombination
- RNA Polymerase I Transcription
- Epigenetic regulation of gene expression
- Negative epigenetic regulation of rRNA expression
- Cell Cycle, Mitotic
- PRC2 methylates histones and DNA
- RMTs methylate histone arginines
- TCF dependent signaling in response to WNT
- Oxidative Stress Induced Senescence
- Homologous Recombination Repair
- RNA Polymerase I Promoter Opening
- Signaling by WNT in cancer
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