SLC12A6 and OXSR1

Number of citations of the paper that reports this interaction (PMID 12386165)
76

Data Source:
HPRD (two hybrid)

		SLC12A6	OXSR1
Gene Name		solute carrier family 12 (potassium/chloride transporter), member 6	oxidative stress responsive 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Potassium Ion Transmembrane Transporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Rubidium Ion Transmembrane Transporter Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Angiogenesis Ion Transport Potassium Ion Transport Potassium Ion Import Rubidium Ion Transport Transmembrane Transport Cellular Hypotonic Response Cellular Hypotonic Salinity Response Chloride Transmembrane Transport	Protein Phosphorylation Response To Oxidative Stress Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs		Potassium Chloride
Diseases
GWAS
Protein-Protein Interactions		2 interactors: OXSR1 STK39	10 interactors: APP BMPR1B PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1
Entrez ID		9990	9943
HPRD ID		09220	06809
Ensembl ID			ENSG00000172939
Uniprot IDs		Q6NSI7 Q9UHW9	O95747
PDB IDs			2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Regulation Of Rubidium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Hypotonic Response Hypotonic Response Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Osmotic Stress Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Peptidyl-threonine Phosphorylation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Potassium Ion Transport Response To Osmotic Stress Negative Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Signal Transduction By Phosphorylation Negative Regulation Of Transport Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Peptidyl-amino Acid Modification Response To Abiotic Stimulus Positive Regulation Of Potassium Ion Transport Protein Phosphorylation Cellular Response To Stress Phosphorylation Intracellular Signal Transduction Peptidyl-serine Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Ion Transport Cellular Protein Modification Process Response To Stress Regulation Of Inflammatory Response Cellular Protein Metabolic Process Response To Oxidative Stress	Response To Osmotic Stress Chloride Transmembrane Transport Chloride Transport Anatomical Structure Development Hyperosmotic Response Potassium Ion Transport Developmental Process Anatomical Structure Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Inorganic Anion Transport Signal Transduction By Phosphorylation Developmental Growth System Development Peptidyl-threonine Phosphorylation Neuromuscular Junction Development Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Guidance BMP Signaling Pathway Anion Transmembrane Transport Positive Regulation Of Cell Volume Rubidium Ion Transport Cellular Hypotonic Salinity Response Cell Morphogenesis Response To Abiotic Stimulus Regulation Of Cartilage Development Neuron Differentiation Response To Stress Epithelial Cell Migration Epithelium Migration Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Ovarian Cumulus Expansion Locomotion Axonogenesis Protein Phosphorylation Axon Development Transepithelial Ammonium Transport Collateral Sprouting In Absence Of Injury Cell Morphogenesis Involved In Neuron Differentiation Dendrite Development Wound Healing
Tagcloud ?		12q23 12q24 14q22 15q11 18p11 22q13 chmp1 citron cux2 drd1 fkbp5 flj32356 g72 gabra5 gchi gpr50 grm3 grm4 htr2a httlpr impa2 mlc1 napg ncam1 pdlim5 period3 syngr1 timeless tph2
Tagcloud (Difference) ?		12q23 12q24 14q22 15q11 18p11 22q13 chmp1 citron cux2 drd1 fkbp5 flj32356 g72 gabra5 gchi gpr50 grm3 grm4 htr2a httlpr impa2 mlc1 napg ncam1 pdlim5 period3 syngr1 timeless tph2
Tagcloud (Intersection) ?