DPH1

Description		diphthamide biosynthesis 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex
	Molecular Function	Protein Binding Transferase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity
	Biological Process	Protein Histidyl Modification To Diphthamide Fibroblast Proliferation
Pathways		Synthesis of diphthamide-EEF2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite ( 28199695)
Interacting Genes		4 interacting genes: HSPA5 RBM8A TFCP2 UBC
Entrez ID		1801
HPRD ID		04634
Ensembl ID		ENSG00000108963
Uniprot IDs		Q9BZG8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum Macromolecule Catabolic Process PERK-mediated Unfolded Protein Response ER Overload Response Post-translational Protein Targeting To Membrane, Translocation Cerebellum Structural Organization Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Cerebellar Purkinje Cell Layer Development Ubiquitin Protein Ligase Binding Protein Folding In Endoplasmic Reticulum Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of IRE1-mediated Unfolded Protein Response U2-type Catalytic Step 1 Spliceosome Exon-exon Junction Subcomplex Mago-y14 Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Protein Tag Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Misfolded Protein Binding Anatomical Structure Arrangement
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