G3BP2 and PHACTR2

		G3BP2	PHACTR2
Description		G3BP stress granule assembly factor 2	phosphatase and actin regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule	Plasma Membrane Membrane Platelet Alpha Granule Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Molecular Condensate Scaffold Activity	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Immune System Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly	Actin Cytoskeleton Organization
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses	Platelet degranulation
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)	3-month functional outcome in non-lacunar ischaemic stroke (modified Rankin score) ( 30796134) Erectile dysfunction in type 1 diabetes ( 22704111) Inflammatory bowel disease ( 23128233) Lung Cancer (DNA repair capacity) ( 23108145) Obesity-related traits ( 23251661) Perceived sweetness of sucrose ( 31005972)
Interacting Genes		68 interacting genes: ANXA1 CEBPA DANCR MDM2 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR19A MIR19B1 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKB1 NFKBIA OGT PDE4B PIN1 PRMT5 RIOK1 TRIM25 USP10 ZNF618
Entrez ID		9908	9749
HPRD ID		06570	16378
Ensembl ID		ENSG00000138757	ENSG00000112419
Uniprot IDs		A0A7I2V3P9 A0A7I2V647 Q9UN86	J3KP75 O75167
PDB IDs		5DRV
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Extracellular Space	Positive Regulation Of Stress Granule Assembly Regulation Of Stress Granule Assembly Stress Granule Assembly Molecular Condensate Scaffold Activity
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