DUSP29 and STX11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DUSP29	STX11
Description		dual specificity phosphatase 29	syntaxin 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Protein-containing Complex	Golgi Apparatus Plasma Membrane Endomembrane System Membrane SNARE Complex Presynaptic Active Zone Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity Protein Homodimerization Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Protein Dephosphorylation Glucose Homeostasis Muscle Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Intracellular Protein Transport Exocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion
Pathways
Drugs
Diseases			Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS			Nicotine dependence symptom count ( 25555482) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		25 interacting genes: AATK ARPC3 ASPA C17orf75 CNTROB DDIT4L EPHA2 ERBB3 GOLGA6A IGF1R LMTK2 LNX1 NIF3L1 NOC4L PICK1 POLR2G PSMB5 PTK7 RNF40 ROR1 ROR2 SRSF11 STX11 TCF4 TEPSIN	98 interacting genes: AIRIM APP AXIN1 AXIN2 BLOC1S6 BYSL CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A MTCL2 NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNCA SNX3 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587
Entrez ID		338599	8676
HPRD ID		16846	09231
Ensembl ID		ENSG00000188716	ENSG00000135604
Uniprot IDs		Q68J44	O75558
PDB IDs		2Y96
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Kinase Activity Glial Cell Development Dendritic Spine Maintenance Coreceptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transferase Activity ATP Binding	Identical Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex SNARE Complex Assembly Protein Binding SNAP Receptor Activity SNARE Complex Synaptic Vesicle Docking Synaptic Vesicle Exocytosis SNARE Binding Regulation Of Cellular Response To Stress Regulation Of DNA Repair BLOC-1 Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Priming Establishment Of Localization In Cell Membrane Docking Establishment Of Organelle Localization Positive Regulation Of Proteolysis Positive Regulation Of Synaptic Transmission Syntaxin Binding Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of RNA Metabolic Process Transcription Coactivator Activity Neurotransmitter Transport Vesicle Fusion Membrane Fusion Long-term Synaptic Potentiation Regulation Of Gene Expression Organelle Membrane Fusion Organelle Localization Establishment Of Vesicle Localization Host-mediated Perturbation Of Symbiont Process DNA Repair-dependent Chromatin Remodeling Regulation Of DNA-templated Transcription Nuclear Androgen Receptor Binding Vesicle Organization Vesicle Docking Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Modulation Of Process Of Another Organism Microtubule-based Process Vesicle Localization Neuron Projection Nucleoplasm
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