ZFYVE16 and MEF2C

Data Source: HiPPIP (Novel)

		ZFYVE16	MEF2C
Name		zinc finger FYVE-type containing 16	myocyte enhancer factor 2C
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Sarcoplasm Nuclear Speck Protein-containing Complex Postsynapse
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Vesicle Organization Endosomal Transport Regulation Of Endocytosis	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Blood Vessel Development Osteoblast Differentiation Neuron Migration B Cell Homeostasis Heart Looping Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Germinal Center Formation Regulation Of Germinal Center Formation Response To Ischemia Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Sinoatrial Valve Morphogenesis Cardiac Ventricle Formation Regulation Of DNA-templated Transcription Apoptotic Process Humoral Immune Response Nervous System Development Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Muscle Cell Fate Determination Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neural Crest Cell Differentiation Myotube Differentiation Cell Differentiation Neuron Differentiation Platelet Formation Negative Regulation Of Ossification Melanocyte Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of B Cell Proliferation Cellular Response To Trichostatin A B Cell Proliferation Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Megakaryocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Positive Regulation Of Skeletal Muscle Tissue Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation B Cell Receptor Signaling Pathway Smooth Muscle Cell Differentiation Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Ventricular Cardiac Muscle Cell Differentiation Regulation Of Synaptic Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Development Renal Tubule Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Behavioral Fear Response Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Signaling by BMP	ERK/MAPK targets Transcriptional activation of mitochondrial biogenesis Myogenesis MECP2 regulates transcription factors Heme signaling Cardiogenesis Expression of BMAL (ARNTL), CLOCK, and NPAS2
Diseases		None	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Blond vs. brown/black hair color ( 30531825 ) Psoriasis ( 25854761 )	Accelerometer-based physical activity measurement (average acceleration) ( 29899525 ) Adult body size ( 32376654 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30643258 ) Alzheimer's disease ( 31473137 ) Alzheimer's disease (late onset) ( 24162737 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Attention deficit hyperactivity disorder ( 29325848 ) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268 ) Body mass index ( 26426971 ) Bone mineral density ( 23572186 24249740 21533022 ) Bone mineral density (hip) ( 19801982 ) Bone mineral density (total hip) ( 29883787 ) Bone mineral density (Ward's triangle area) ( 27397699 ) Caffeine consumption from coffee ( 33287642 ) Chronotype ( 30696823 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Depression ( 29700475 ) Femoral neck bone mineral density ( 32239398 29499414 22504420 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) General cognitive ability ( 29844566 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) Height ( 20881960 25282103 25429064 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Household income (MTAG) ( 31844048 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Lamb consumption ( 32066663 ) Lymphocyte percentage of white cells ( 32888494 ) Major depressive disorder ( 27479909 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 27863252 ) Mean platelet volume ( 27863252 22139419 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Morning person ( 30696823 ) Multiple sclerosis ( 31604244 ) Number of sexual partners ( 30643258 ) Photic sneeze reflex ( 27182965 ) Platelet count ( 32888494 27863252 22139419 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Red blood cell count ( 27863252 32888494 ) Refractive error ( 32231278 ) Regular attendance at a religious group ( 29970889 ) Retinal arteriolar caliber ( 23776548 ) Retinal vascular caliber ( 21060863 ) Rosacea symptom severity ( 29771307 ) Schizophrenia ( 25056061 30285260 ) Serum alkaline phosphatase levels ( 33547301 ) Smoking status (ever vs never smokers) ( 30643258 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Tonometry ( 17903302 ) Vascular endothelial growth factor levels ( 26910538 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 )
Novel Interactors		1 novel interactors: MEF2C	6 novel interactors: COX7C EDIL3 NR2F1 SEC23A TICAM2 ZFYVE16
Interacting Genes		6 interacting genes: APP EEA1 PPP1CA RNF11 TOM1 UBC	31 interacting genes: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 KPNA4 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 TEAD1 TWIST2 UBE2I VGLL2 VGLL4 YWHAZ
Entrez ID		9765	4208
HPRD ID		10319	02809
Ensembl ID		ENSG00000039319	ENSG00000081189
Uniprot IDs		Q7Z3T8	A0A0D9SFD0 A0A0D9SGI5 A0A0R4J2G5 A0A9L9PYA3 D8L7E9 Q06413
PDB IDs		3T7L 5MK0	Not available
GO Terms Enriched among Interactors		NMDA Selective Glutamate Receptor Signaling Pathway Early Endosome Response To Lead Ion Recycling Endosome Transition Metal Ion Binding Extracellular Exosome Early Endosome Membrane Ionotropic Glutamate Receptor Signaling Pathway Postsynapse Positive Regulation Of Protein-containing Complex Disassembly Endosome Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Metal Ion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Sinoatrial Valve Morphogenesis Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Programmed Cell Death Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Macrophage Apoptotic Process Primary Heart Field Specification Muscle Cell Fate Determination Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Vesicle Fusion Organelle Membrane Fusion	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Myotube Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Nucleoplasm DNA-binding Transcription Activator Activity Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Fate Commitment Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Regulation Of Developmental Process Striated Muscle Tissue Development Protein Lysine Deacetylase Activity Negative Regulation Of Metabolic Process Chromatin Regulation Of Cardiac Muscle Cell Proliferation Muscle Tissue Development Regulation Of Muscle Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Histone Deacetylase Activity Heart Development DNA-binding Transcription Factor Activity