RUBCN and ZFYVE21

Number of citations of the paper that reports this interaction (PubMedID 37225719)
40

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		RUBCN	ZFYVE21
Description		rubicon autophagy regulator	zinc finger FYVE-type containing 21
Image
GO Annotations	Cellular Component	Nucleoplasm Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol	Endosome Focal Adhesion Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Phosphatidylinositol Phosphate Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Immune System Process Endocytosis Phagocytosis Autophagy Negative Regulation Of Autophagy Negative Regulation Of Endocytosis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multivesicular Body Sorting Pathway Negative Regulation Of Autophagosome Maturation
Pathways
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971) Hemoglobin ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		18 interacting genes: ANKRD11 BRD1 BYSL DPF2 DRC4 ENKD1 EXOC1 FAM161A FAM9B NME7 PYCARD RNF34 SMAD9 TCEANC VEZF1 ZFYVE21 ZNF250 ZNF648	28 interacting genes: AGTRAP ARL6IP1 CAPN2 CMTM4 FBXO7 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP5-9 MID2 MTUS2 NOTCH2NLA PDE4DIP PTK2 PYCARD RABAC1 REEP6 RTN4 RUBCN SIAH1 SMIM5 TRAF1 TRIM27 TUBB YIF1A
Entrez ID		9711	79038
HPRD ID		11069	15733
Ensembl ID		ENSG00000145016	ENSG00000100711
Uniprot IDs		A0A9L9PY84 Q8N4U6 Q92622	Q9BQ24
PDB IDs		6WCW	2RRF
Enriched GO Terms of Interacting Partners?			Intermediate Filament Keratin Filament Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Endoplasmic Reticulum Tubular Network Formation Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Endoplasmic Reticulum Tubular Network Membrane Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Endoplasmic Reticulum Organization Structural Molecule Activity Intermediate Filament Organization Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Viral Transcription Regulation Of Autophagy Endoplasmic Reticulum Membrane Organization Suppression Of Viral Release By Host Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Viral Transcription Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Mononuclear Cell Migration Endoplasmic Reticulum Tubular Network Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Cellular Response To Fluid Shear Stress Regulation Of Cytoskeleton Organization Cytosol Ubiquitin Protein Ligase Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Myosin I Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Mononuclear Cell Migration Cytoskeleton Positive Regulation Of Leukocyte Migration Regulation Of Macrophage Cytokine Production Regulation Of Programmed Cell Death Microtubule Response To Fluid Shear Stress
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