RUBCN and DPF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RUBCN	DPF2
Description		rubicon autophagy regulator	double PHD fingers 2
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GO Annotations	Cellular Component	Nucleoplasm Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SWI/SNF Complex NBAF Complex
	Molecular Function	Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Phosphatidylinositol Phosphate Binding	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity Histone H3K14ac Reader Activity Histone H4K16ac Reader Activity
	Biological Process	Immune System Process Endocytosis Phagocytosis Autophagy Negative Regulation Of Autophagy Negative Regulation Of Endocytosis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Multivesicular Body Sorting Pathway Negative Regulation Of Autophagosome Maturation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of G0 To G1 Transition Apoptotic Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways			Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Mean spheric corpuscular volume ( 32888494) Urate levels ( 31578528)
Interacting Genes		18 interacting genes: ANKRD11 BRD1 BYSL DPF2 DRC4 ENKD1 EXOC1 FAM161A FAM9B NME7 PYCARD RNF34 SMAD9 TCEANC VEZF1 ZFYVE21 ZNF250 ZNF648	20 interacting genes: FHL2 GOLGA6L9 H3-4 H3C1 H4C1 HSF2BP LDOC1 LNX1 MEOX2 NFKB2 PICK1 REL RELB RINT1 RUBCN TTC23L TXNDC12 UPF2 ZNF212 ZNF655
Entrez ID		9711	5977
HPRD ID		11069	03394
Ensembl ID		ENSG00000145016	ENSG00000133884
Uniprot IDs		A0A9L9PY84 Q8N4U6 Q92622	J3KMZ8 Q92785
PDB IDs		6WCW	3IUF 5B79 5VDC 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?			NF-kappaB Complex Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interferon-beta Production Structural Constituent Of Chromatin Response To Muramyl Dipeptide Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm
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