VPS26A and DEDD

		VPS26A	DEDD
Description		VPS26 retromer complex component A	death effector domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Cytosol Endosome Membrane Membrane Retromer Complex Retromer, Cargo-selective Complex Vesicle Tubular Endosome	Nucleus Nucleolus Cytoplasm
	Molecular Function	Protein Binding	DNA Binding Protein Binding
	Biological Process	Intracellular Protein Transport Protein Transport Regulation Of Macroautophagy Endocytic Recycling Retrograde Transport, Endosome To Golgi	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways		WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Glycemic traits (pregnancy) ( 23903356) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Type 2 diabetes ( 21874001 30718926)
Interacting Genes		3 interacting genes: MORF4L1 VPS26C ZSCAN12	16 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3
Entrez ID		9559	9191
HPRD ID		08385	06022
Ensembl ID		ENSG00000122958	ENSG00000158796
Uniprot IDs		B4DLT1 O75436	B1AQP5 O75618
PDB IDs		2FAU 5F0J 5F0L 5F0M 5F0P 7BLO
Enriched GO Terms of Interacting Partners?			Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation
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