CHD1L and SCYL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CHD1L	SCYL1
Description		chromodomain helicase DNA binding protein 1 like	SCY1 like pseudokinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Site Of Double-strand Break Site Of DNA Damage	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Centrosome Cytosol Cytoskeleton Membrane COPI Vesicle Coat
	Molecular Function	Nucleotide Binding DNA Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Reader Activity ATP-dependent Chromatin Remodeler Activity Poly-ADP-D-ribose Modification-dependent Protein Binding	DNA Binding Protein Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	DNA Repair Chromatin Remodeling DNA Damage Response	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Inflammatory Response Intracellular Protein Localization Vesicle-mediated Transport Spinal Cord Motor Neuron Differentiation Neuron Development
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Grn163l
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 25760438)	Acne (severe) ( 24927181) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femoral neck bone mineral density ( 22504420) Hip index ( 34021172) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946)
Interacting Genes		6 interacting genes: BAALC CTCF NR4A1 SCYL1 SRPK2 TRIM33	21 interacting genes: APP ARF1 ARF3 AXIN1 CCNF CD93 CDC25A CHD1L COIL COPA COPE DAPK1 DDX6 GORAB LENG1 NOD2 PIN1 PLEKHF2 SMURF1 SNCA TCEA2
Entrez ID		9557	57410
HPRD ID		09880	06414
Ensembl ID		ENSG00000131778	ENSG00000142186
Uniprot IDs		A0A0A0MRH8 A0A0A0MSH9 Q86WJ1	E9PK59 E9PPN3 Q96KG9
PDB IDs		6ZHX 6ZHY 7ENN 7EPU 7OTQ 8B0A
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Catabolic Process Intracellular Transport Regulation Of Protein Metabolic Process Vesicle-mediated Transport Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Macrophage Activation Protein Localization To Axon Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Protein Domain Specific Binding COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat I-SMAD Binding Positive Regulation Of JNK Cascade Cellular Localization Regulation Of Neurotransmitter Uptake Copper Ion Homeostasis Transport Vesicle Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cytoplasmic Vesicle R-SMAD Binding Myeloid Leukocyte Activation Amyloid Fibril Formation Establishment Of Protein Localization Growth Cone Microglial Cell Activation Negative Regulation Of Protein Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Golgi Apparatus Mitotic Cleavage Furrow Ingression Intra-Golgi Vesicle-mediated Transport DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cis-trans Isomerase Activity
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