DENR and MCTS1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, cross-linking study), HPRD (two hybrid)

		DENR	MCTS1
Name		density regulated re-initiation and release factor	MCTS1 re-initiation and release factor
Structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm
	Molecular Function	Translation Initiation Factor Activity Protein Binding	RNA Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process	Formation Of Translation Preinitiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Ribosome Disassembly IRES-dependent Viral Translational Initiation	Formation Of Translation Preinitiation Complex Translation Reinitiation Translation Translational Initiation DNA Damage Response Ribosome Disassembly IRES-dependent Viral Translational Initiation
GWAS		Apolipoprotein A1 levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: SCARB1	1 novel interactors: KMT2A
Interacting Genes		3 interacting genes: MCTS1 NELFB UBC	2 interacting genes: CEBPA DENR
Entrez ID		8562	28985
HPRD ID		05182	06634
Ensembl ID		ENSG00000139726	ENSG00000232119
Uniprot IDs		O43583	Q9ULC4
PDB IDs		5ONS 5VYC 6MS4 6VPQ 6VPR	3R90 5ONS 5VYC 6MS4
GO Terms Enriched among Interactors		Endocytic Vesicle Membrane Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity High Density Lipoprotein Particle Mediated Signaling Regulation Of Sphingolipid Mediated Signaling Pathway Lipopolysaccharide Transport Cholesterol Catabolic Process Recognition Of Apoptotic Cell Lipopolysaccharide Immune Receptor Activity Positive Regulation Of Cholesterol Storage Positive Regulation Of Nitric Oxide Mediated Signal Transduction Cholesterol Import Detection Of Lipopolysaccharide Regulation Of Phospholipid Catabolic Process Apolipoprotein A-I Binding High-density Lipoprotein Particle Clearance Regulation Of Phosphatidylcholine Catabolic Process NELF Complex Translation Reinitiation Formation Of Translation Preinitiation Complex Detection Of Molecule Of Bacterial Origin Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Nitric Oxide Mediated Signal Transduction High-density Lipoprotein Particle Binding Intestinal Lipid Absorption Phagocytosis, Recognition RNA Binding RNA Cap Binding IRES-dependent Viral Translational Initiation Adhesion Of Symbiont To Host 1-phosphatidylinositol Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Low-density Lipoprotein Particle Clearance Reverse Cholesterol Transport Vitamin Transmembrane Transport Protein Tag Activity Regulation Of Triglyceride Biosynthetic Process High-density Lipoprotein Particle Remodeling Ribosomal Small Subunit Binding Positive Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Steroid Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Scavenger Receptor Activity Negative Regulation Of Stem Cell Differentiation Negative Regulation Of DNA-templated Transcription, Elongation Plasma Lipoprotein Particle Clearance Intestinal Absorption	Leukocyte Differentiation Learning Or Memory Cognition CHOP-C/EBP Complex Response To Phenylpropanoid Mononuclear Cell Differentiation Embryonic Organ Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Metal Ion Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Translation Reinitiation Formation Of Translation Preinitiation Complex Urea Cycle STAT Family Protein Binding IRES-dependent Viral Translational Initiation Urea Metabolic Process HMG Box Domain Binding Response To Lithium Ion Transcription By RNA Polymerase I Chromatin Binding Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Multicellular Organismal-level Homeostasis Osteoblast Development Definitive Hemopoiesis Histone H3K4 Methyltransferase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Response To Potassium Ion Embryonic Hemopoiesis Epithelial Cell Maturation Regulation Of Chromatin Organization Hematopoietic Stem Cell Proliferation