FADS2 and RAD51B

		FADS2	RAD51B
Description		fatty acid desaturase 2	RAD51 paralog B
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	Stearoyl-CoA 9-desaturase Activity Protein Binding Acyl-CoA 6-desaturase Activity Acyl-CoA Desaturase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity
	Biological Process	Arachidonate Metabolite Production Involved In Inflammatory Response Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Cellular Response To Oxidative Stress Fatty Acid Derivative Biosynthetic Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Blastocyst Growth DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Somite Development
Pathways		Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism alpha-linolenic acid (ALA) metabolism	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 Factors involved in megakaryocyte development and platelet production
Drugs		alpha-Linolenic acid
Diseases
GWAS		Alanine aminotransferase levels ( 33339817) Albumin-globulin ratio ( 29403010) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic valve stenosis ( 32186652) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Asthma ( 31619474 31959851 32296059) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756 34002096) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 19060911 20686565 24097068 25961943) Cholesteryl ester levels ( 31551469) Colorectal cancer ( 24836286) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 28067908) Daytime nap ( 33568662) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Fatty acid desaturase activity (serum) ( 30453627) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 24647736 28898252) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 19060906 19060911 20686565 24097068 25961943) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) IgA levels ( 28628107) Inflammatory bowel disease ( 23128233) Iron status biomarkers (transferrin levels) ( 25352340) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 19060910 19060911 20686565 24097068 25961943) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer in ever smokers ( 28604730) Lymphocyte percentage of white cells ( 32888494) Lysophosphatidylcholine levels ( 31551469) Lysophosphatidylethanolamine levels ( 31551469) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 20694148 31589552) Metabolite levels ( 22916037 23378610 23823483) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 32888494) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Oleic acid (18:1n-9) levels ( 23362303 28298293) P wave duration ( 24850809) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Phosphatidylcholine levels ( 31551469) Phosphatidylcholine-ether levels ( 31551469) Phosphatidylethanolamine levels ( 31551469) Phosphatidylethanolamine-ether levels ( 31551469) Phosphatidylinositol levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) PR interval ( 32439900) Pulse pressure ( 30578418) QRS duration ( 27659466) QT interval ( 24952745 29874175) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 27798624 29769521) Rheumatoid arthritis ( 24390342 30423114) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 29545352 33838163) Serum metabolite levels ( 23093944 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Sphingolipid levels ( 22359512) Sphingomyelin levels ( 31551469) Stearic acid (18:0) levels ( 23362303) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29403010 33339817) Triacylglyceride levels ( 31551469) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 28334899 30698716 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 19060906 20686565 24097068 25961943) Type 1 diabetes ( 34127860) Urate levels ( 31578528) Vaccenic acid (18:1n-7) levels ( 28298293) Vitiligo ( 27723757)	Advanced age-related macular degeneration ( 26691988) Adverse response to drug ( 30420678) Age-related macular degeneration ( 23455636) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 32296059 30929738 31361310 31619474 31959851 34103634 27182965) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Brain asymmetrical skew (vertical) ( 33836062) Breast cancer ( 29059683) Breast cancer (male) ( 23001122) Cancer (pleiotropy) ( 27197191) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Granulocyte count ( 27863252) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Nose size ( 27182965) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes ( 34127860) Type 2 diabetes nephropathy ( 30566433) White blood cell count ( 32888494 27863252)
Interacting Genes		7 interacting genes: ATXN1L GRSF1 KRT31 KRT40 NBPF19 NOTCH2NLA ZNF655	11 interacting genes: ABL1 FAM9B H1-0 H2BC8 H3C1 H4C14 MEOX2 RAD51C RAD51D RPAIN SWSAP1
Entrez ID		9415	5890
HPRD ID		05854	04255
Ensembl ID		ENSG00000134824	ENSG00000182185
Uniprot IDs		O95864	C9JYJ0 O15315
PDB IDs			8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?			Chromosome Organization Four-way Junction DNA Binding Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleosome Assembly DNA Binding Nucleosome Nucleosome Organization Telomere Organization Rad51B-Rad51C-Rad51D-XRCC2 Complex Chromosome Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Protein-containing Complex Assembly Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Protein-containing Complex Organization Replication Fork Reciprocal Meiotic Recombination Nucleoplasm DNA Repair Homologous Recombination Double-strand Break Repair DNA Recombination Negative Regulation Of DNA Recombination Regulation Of Cell Migration Involved In Sprouting Angiogenesis Protein Localization To Cytoplasmic Microtubule Plus-end Female Meiosis Sister Chromatid Cohesion Chromatin Remodeling Transitional One Stage B Cell Differentiation DNA Metabolic Process Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Positive Regulation Of Cellular Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Acyl-CoA Desaturase Activity Shu Complex Protein Heterodimerization Activity DNA Damage Response Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Chromatin Organization Positive Regulation Of Response To Oxidative Stress Stearoyl-CoA 9-desaturase Activity Telomere Maintenance
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